Synthesis and biological evaluation of some coumarin hybrids as selective carbonic anhydrase IX and XII inhibitors.
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DOI: 10.1016/j.bioorg.2020.104272
Abstract: Two series, coumarin-linked to thiazolidinone via a pyrazole linker (6a-m, Series 1) and coumarin-linked 1,2,3-triazoles (5a-j, Series 2) were synthesized and the synthesized compounds were subjected for evaluation against the four physiologically and pharmacologically relevant… read more here.
Keywords: coumarin; xii inhibitors; inhibition; series ... See more keywords
Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation
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DOI: 10.1080/14756366.2019.1697250
Abstract: Abstract Pursuing on our efforts toward searching for efficient hCA IX and hCA XII inhibitors, herein we report the design and synthesis of new sets of benzofuran-based sulphonamides (4a,b, 5a,b, 9a–c, and 10a–d), featuring the… read more here.
Keywords: based sulphonamides; xii inhibitors; novel benzofuran; hca xii ... See more keywords
7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors
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DOI: 10.1080/14756366.2020.1722658
Abstract: Abstract A series of 3H-1,2-benzoxathiepine 2,2-dioxides incorporating 7-acylamino moieties were obtained by an original procedure starting from 5-nitrosalicylaldehyde, which was treated with propenylsulfonyl chloride followed by Wittig reaction of the bis-olefin intermediate. The new derivatives,… read more here.
Keywords: benzoxathiepine dioxides; carbonic anhydrase; xii inhibitors;