Trisomy silencing by XIST normalizes Down syndrome cell pathogenesis demonstrated for hematopoietic defects in vitro
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DOI: 10.1038/s41467-018-07630-y
Abstract: We previously demonstrated that an integrated XIST transgene can broadly repress one chromosome 21 in Down syndrome (DS) pluripotent cells. Here we address whether trisomy-silencing can normalize cell function and development sufficiently to correct cell… read more here.
Keywords: silencing xist; pathogenesis; xist normalizes; cell pathogenesis ... See more keywords