Developmental Xist induction is mediated by enhanced splicing
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1198
Abstract: Abstract X-inactive-specific transcript (Xist) is a long noncoding RNA (lncRNA) essential for inactivating one of the two X chromosomes in mammalian females. Random X chromosome inactivation is mediated by Xist RNA expressed from the inactive… read more here.
Keywords: xist rna; xist; rna; xist splicing ... See more keywords
Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases.
Sign Up to like & getrecommendations! Published in 2019 at "JCI insight"
DOI: 10.1172/jci.insight.126751
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disorder that predominantly affects women and is driven by autoreactive T cell-mediated inflammation. It is known that individuals with multiple X-chromosomes are at increased risk for developing SLE;… read more here.
Keywords: xist rna; cells sle; altered chromosome; inactivation cells ... See more keywords
The 5' region of Xist RNA has the potential to associate with chromatin through the A-repeat.
Sign Up to like & getrecommendations! Published in 2017 at "RNA"
DOI: 10.1261/rna.062158.117
Abstract: X inactive-specific transcript (Xist) is a long noncoding RNA that plays an essential role in X chromosome inactivation. Although Xist RNA, like common protein-coding mRNAs, is transcribed by RNA polymerase II, spliced and polyadenylated, it… read more here.
Keywords: rna potential; xist rna; xist; potential associate ... See more keywords