SPEN is required for Xist upregulation during initiation of X chromosome inactivation
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DOI: 10.1038/s41467-021-27294-5
Abstract: At initiation of X chromosome inactivation (XCI), Xist is monoallelically upregulated from the future inactive X (Xi) chromosome, overcoming repression by its antisense transcript Tsix. Xist recruits various chromatin remodelers, amongst them SPEN, which are… read more here.
Keywords: xist upregulation; initiation; initiation chromosome; chromosome inactivation ... See more keywords