DNA repair protein XPA is differentially expressed in colorectal cancer and predicts better prognosis
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1480
Abstract: As an indispensable factor in DNA damage recognition step of nucleotide excision repair, XPA interacts with a series of proteins to initiate repair process. The expression characteristics of XPA in colorectal cancer (CRC) and its… read more here.
Keywords: xpa; prognosis; expression; crc ... See more keywords
ERCC1, XPF and XPA—locoregional differences and prognostic value of DNA repair protein expression in patients with head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-018-2751-0
Abstract: ObjectivesNucleotide excision repair protein expression has been claimed to be responsible for platinum-based chemotherapy resistance. ERCC1, XPF and XPA, core proteins in DNA repair, were evaluated regarding their prognostic value in patients with head and… read more here.
Keywords: protein expression; xpa; cell carcinoma; squamous cell ... See more keywords
Differential sensitivities of cellular XPA and PARP‐1 to arsenite inhibition and zinc rescue
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.05.031
Abstract: &NA; Arsenite directly binds to the zinc finger domains of the DNA repair protein poly (ADP ribose) polymerase (PARP)‐1, and inhibits PARP‐1 activity in the base excision repair (BER) pathway. PARP inhibition by arsenite enhances… read more here.
Keywords: dna damage; xpa; zinc; xpa parp ... See more keywords
A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208860120
Abstract: Significance Nucleotide excision DNA repair (NER) removes a large variety of genomic lesions. NER can be initiated through two distinct pathways: global genome repair (GG-NER) and transcription-coupled repair (TC-NER). Both pathways subsequently funnel into a… read more here.
Keywords: xpa; transcription; nucleotide excision; transcription coupled ... See more keywords
Diffusion of nucleotide excision repair protein XPA along DNA by coarse-grained molecular simulations
Sign Up to like & getrecommendations! Published in 2021 at "Chinese Physics B"
DOI: 10.1088/1674-1056/ac1e0e
Abstract: Protein XPA plays critical roles in nucleotide excision repair pathway. Recent experimental work showed that the functional dynamics of XPA involves the one-dimensional diffusion along DNA to search the damage site. Here, we investigate the… read more here.
Keywords: protein xpa; xpa; diffusion; nucleotide excision ... See more keywords
A key interaction with RPA orients XPA in NER complexes
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz1231
Abstract: Abstract The XPA protein functions together with the single-stranded DNA (ssDNA) binding protein RPA as the central scaffold to ensure proper positioning of repair factors in multi-protein nucleotide excision repair (NER) machinery. We previously determined… read more here.
Keywords: dbd rpa70ab; xpa; ner; xpa dbd ... See more keywords
XPA Enhances Temozolomide Resistance of Glioblastoma Cells by Promoting Nucleotide Excision Repair
Sign Up to like & getrecommendations! Published in 2022 at "Cell Transplantation"
DOI: 10.1177/09636897221092778
Abstract: Glioblastoma is the most frequent, as well as aggressive kind of high-grade malignant glioma. Chemoresistance is posing a significant clinical barrier to the efficacy of temozolomide-based glioblastoma treatment. By suppressing xeroderma pigmentosum group A (XPA),… read more here.
Keywords: glioblastoma; xpa; nucleotide excision; temozolomide resistance ... See more keywords
Increased levels of XPA might be the basis of cisplatin resistance in germ cell tumours
Sign Up to like & getrecommendations! Published in 2020 at "BMC Cancer"
DOI: 10.1186/s12885-019-6496-1
Abstract: BackgroundGerm cell tumours (GCTs) represent a highly curable malignity as they respond well to cisplatin (CDDP)-based chemotherapy. Nevertheless, a small proportion of GCT patients relapse or do not respond to therapy. As this might be… read more here.
Keywords: xpa; gct patients; expression; cell ... See more keywords
Nucleotide Excision Repair Pathway Activity Is Inhibited by Airborne Particulate Matter (PM10) through XPA Deregulation in Lung Epithelial Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23042224
Abstract: Airborne particulate matter with a diameter size of ≤10 µm (PM10) is a carcinogen that contains polycyclic aromatic hydrocarbons (PAH), which form PAH–DNA adducts. However, the way in which these adducts are managed by DNA… read more here.
Keywords: airborne particulate; xpa; lung; activity ... See more keywords