Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-&kgr;B and AP-1 signalling
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DOI: 10.1093/cvr/cvx198
Abstract: Aims Spironolactone (SPL) improves endothelial dysfunction and survival in heart failure. Immune modulation, including poorly understood mineralocorticoid receptor (MR)-independent effects of SPL might contribute to these benefits and possibly be useful in other inflammatory cardiovascular… read more here.
Keywords: xpb; degradation; suppression; spl ... See more keywords
Human T-Cell Lymphotropic Virus Type 1 Transactivator Tax Exploits the XPB Subunit of TFIIH during Viral Transcription
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DOI: 10.1128/jvi.02171-19
Abstract: HTLV-1 is considered the most potent human oncovirus and is also responsible for severe inflammatory disorders. HTLV-1 transcription is undertaken by RNA polymerase II and is controlled by the viral oncoprotein Tax. Tax transactivates the… read more here.
Keywords: xpb; htlv; transcription; promoter ... See more keywords
Spironolactone and XPB: An Old Drug with a New Molecular Target
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DOI: 10.3390/biom10050756
Abstract: Spironolactone (SP) is commonly used for the treatment of heart failure, hypertension, and complications of cirrhosis by antagonizing the mineralocorticoid receptor. However, SP also antagonizes the androgen receptor, and thus SP has also been shown… read more here.
Keywords: xpb; xpb old; old drug; drug new ... See more keywords