Spironolactone-induced degradation of the TFIIH core complex XPB subunit suppresses NF-&kgr;B and AP-1 signalling
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DOI: 10.1093/cvr/cvx198
Abstract: Aims Spironolactone (SPL) improves endothelial dysfunction and survival in heart failure. Immune modulation, including poorly understood mineralocorticoid receptor (MR)-independent effects of SPL might contribute to these benefits and possibly be useful in other inflammatory cardiovascular… read more here.
Keywords: xpb; degradation; suppression; spl ... See more keywords