Association between polymorphisms of Xeroderma pigmentosum complementation group C gene (XPC) and susceptibility to schizophrenia.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.02.018
Abstract: Previous studies revealed that polymorphisms in several DNA repair genes are associated with the risk of schizophrenia. The relationship between three polymorphisms (Ala499Val, PAT, and Lys939Gln) of the XPC (MIM: 613208) and the risk of… read more here.
Keywords: schizophrenia; association; risk schizophrenia; xpc ... See more keywords
Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein
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DOI: 10.1016/j.isci.2022.104040
Abstract: Summary The XPC protein complex plays a central role in DNA lesion recognition for global genome nucleotide excision repair (GG-NER). Lesion recognition can be accomplished in either a UV-DDB-dependent or -independent manner; however, it is… read more here.
Keywords: xpc protein; nucleotide excision; histone deacetylation; xpc ... See more keywords
Inhibition of Excison of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B.
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DOI: 10.1021/acs.biochem.0c00080
Abstract: The interplay between nucleotide excision repair (NER) and base excision repair (BER) of non-bulky, oxidatively generated DNA lesion, has long been a subject of significant interest. The hydantoin oxidation products of 8-oxoguanine, spiroiminodihydantoin (Sp) and… read more here.
Keywords: xpc; factor; nucleotide excision; excision repair ... See more keywords
CSB-independent, XPC-dependent transcription-coupled repair in Drosophila
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123163119
Abstract: Significance We have discovered that Drosophila, which does not have the canonical TCR homologs, does nevertheless carry out TCR as efficiently as organisms that do. Furthermore, using the XR-seq and in vivo excision assay we… read more here.
Keywords: xpc dependent; independent xpc; dependent transcription; xpc ... See more keywords
Phosphorylation of xeroderma pigmentosum group C regulates ultraviolet-induced DNA damage repair
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DOI: 10.1093/nar/gky239
Abstract: Abstract Nucleotide excision repair (NER) is the most versatile DNA repair system that removes bulky DNA damage induced by various endogenous and exogenous factors, including UV radiation. Defects in NER can lead to the xeroderma… read more here.
Keywords: dna damage; xeroderma pigmentosum; xpc; phosphorylation ... See more keywords
遗传性皮肤病中的纤维母细胞活化和 ECM 重塑
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18285
Abstract: 隐性营养不良性大疱性表皮松解症(RDEB)、Kindler综合征 (KS) 和 C 组着色性干皮病(XPC) 是三种令患者发生癌症风险增加的遗传性皮肤疾病(遗传性皮肤病) 。仍未充分了解在这些疾病中导致癌症的事件, 包括在皮肤水平发生的事件, 尽管已对它们进行了深入调查。为了加深对于这些罕见病的认识,最终发现新的治疗, 西班牙研究小组调查了来自 RDEB、KS 和 XPC 患者的一种称为真皮纤维母细胞的皮肤细胞的基因表达谱 (标签) 。研究者们发现, 来自这三种遗传皮肤病的纤维母细胞都有大量以相同方式异常(错误)表达的基因。它们反过来转化成一种活化表型, 导致真皮 (一层皮肤) 硬度变化和氧化还原 (一种化学反应)状态失衡。这一重叠标签似乎不依赖于导致缺乏缺陷 (即 VII 型胶原、kindlin‐1 或 XPC 的丢失) 的原发疾病,而是尚未充分了解的常见损伤‐反应性事件的结果。总而言之, 该研究为真皮纤维母细胞在 RDEB、XPC 和 KS 中所扮演角色添加了最新认识, 并强调了可能的新治疗靶点。 read more here.
Keywords: xpc; dermatology;
HDAC3 Is Required for XPC Recruitment and Nucleotide Excision Repair of DNA Damage Induced by UV Irradiation
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DOI: 10.1158/1541-7786.mcr-20-0214
Abstract: Recent studies have demonstrated that lysine acetylation of histones is crucial for nucleotide excision repair (NER) by relaxing the chromatin structure, which facilitates the recruitment of repair factors. However, few studies have focused on the… read more here.
Keywords: xpc; hdac3; nucleotide excision; irradiation ... See more keywords
Xeroderma Pigmentosum Group C Deficiency Alters Cigarette Smoke DNA Damage Cell Fate and Accelerates Emphysema Development
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DOI: 10.1165/rcmb.2017-0251oc
Abstract: Abstract Cigarette smoke (CS) exposure is a major risk factor for the development of emphysema, a common disease characterized by loss of cells comprising the lung parenchyma. The mechanisms of cell injury leading to emphysema… read more here.
Keywords: dna damage; exposure; xpc; cell ... See more keywords
PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts
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DOI: 10.1590/1678-4685-gmb-2019-0083
Abstract: Abstract The XPC protein, which is mutated in xeroderma pigmentosum (XP) complementation group C (XP-C), is a lesion recognition factor in NER, but it has also been shown to interact with and stimulate DNA glycosylases,… read more here.
Keywords: pgc expression; cell lines; expression; pgc ... See more keywords