COL4A1, negatively regulated by XPD and miR-29a-3p, promotes cell proliferation, migration, invasion and epithelial–mesenchymal transition in liver cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02611-y
Abstract: Collagen type IV alpha 1 (COL4A1) exerts tumor-promoting functions in several tumors. However, its role in liver cancer remains not fully understood. Hence, this study aims to investigate the role of COL4A1 in regulating liver… read more here.
Keywords: col4a1; proliferation migration; mir 29a; xpd ... See more keywords
Phosphorylation of XPD drives its mitotic role independently of its DNA repair and transcription functions
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abp9457
Abstract: The helicase XPD is known as a key subunit of the DNA repair/transcription factor TFIIH. However, here, we report that XPD, independently to other TFIIH subunits, can localize with the motor kinesin Eg5 to mitotic… read more here.
Keywords: dna repair; xpd; repair transcription; phosphorylation ... See more keywords
Crumbs, Galla and Xpd are required for kinesin-5 regulation in mitosis and organ growth in Drosophila.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.246801
Abstract: Xeroderma Pigmentosum D (XPD) is a multi-function protein involved in transcription, DNA repair, and chromosome segregation. In Drosophila, Xpd interacts with Crumbs (Crb) and Galla to regulate mitosis during embryogenesis. It is unknown how these… read more here.
Keywords: drosophila; mitosis; xpd; crb galla ... See more keywords
DNA repair gene (XRCC1 and XPD) polymorphism and risk of primary ovarian failure.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202209_29759
Abstract: OBJECTIVE DNA repair genes may be related with the onset of primary ovarian failure (POF). The study was planned to investigate whether the polymorphisms in the DNA repair genes modulate the risk of POF. PATIENTS… read more here.
Keywords: dna repair; polymorphism; xrcc1; xpd ... See more keywords
XPD inhibits cell growth and invasion and enhances chemosensitivity in esophageal squamous cell carcinoma by regulating the PI3K/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2020.4593
Abstract: Esophageal squamous cell carcinoma (ESCC) is a lethal disease due to its high aggressiveness. The aim of the present study was to investigate the role of xeroderma pigmentosum complementation group D (XPD) in the growth… read more here.
Keywords: xpd; invasion; ec9706 ec109; pi3k akt ... See more keywords