Inhibition of XPO1 impairs cholangiocarcinoma cell proliferation by triggering p53 intranuclear accumulation
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DOI: 10.1002/cam4.5322
Abstract: XPO1 mediates the nuclear export of several proteins, mainly tumor suppressors. KPT‐330 (Selinexor) is a selective inhibitor of XPO1 that has demonstrated good therapeutic effects in hematologic cancers. read more here.
Keywords: cell proliferation; xpo1; cholangiocarcinoma cell; inhibition xpo1 ... See more keywords
XPO1 Gene Therapy Attenuates Cardiac Dysfunction in Rats with Chronic Induced Myocardial Infarction
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DOI: 10.1007/s12265-019-09932-y
Abstract: Transcriptomic signature of XPO1 was highly expressed and inversely related to left ventricular function in ischemic cardiomyopathy patients. We hypothesized that treatment with AAV9-shXPO1 attenuates left ventricular dysfunction and remodeling in a myocardial infarction rat… read more here.
Keywords: aav9 shxpo1; dysfunction; myocardial infarction; left ventricular ... See more keywords
Proteomics identify nuclear export as a targetable pathway in neuroblastoma: Comment on “XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IκB”
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101150
Abstract: Neuroblastoma (NBL) is an embryonal malignancy of childhood with poor outcomes for patient with high-risk disease. Multimodal treatment approaches have improved outcomes but at the cost of significant toxicity, and there is no durable therapeutic… read more here.
Keywords: export; nuclear export; inhibition; identify nuclear ... See more keywords
The nuclear export protein XPO1 — from biology to targeted therapy
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DOI: 10.1038/s41571-020-00442-4
Abstract: Exportin 1 (XPO1), also known as chromosome region maintenance protein 1, plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of cargoes, including proteins and several classes of RNAs,… read more here.
Keywords: protein; export; nuclear export; biology ... See more keywords
Abstract 464: Novel role of xpo1 in regulating MicroRNAs related to pancreatic ductal adenocarcinoma invasion and metastasis
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DOI: 10.1158/1538-7445.am2017-464
Abstract: Objective: There are no known reports on the role of exportin 1 (XPO1; also known as chromosome maintenance region 1 [CRM1]) in microRNA biology. In this study, we for the first time demonstrate that interfering… read more here.
Keywords: ductal adenocarcinoma; mir 145; invasion; pancreatic ductal ... See more keywords
Abstract 1652: A novel reversible inhibitor of XPO1 with potent efficacy in multiple preclinical mouse models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1652
Abstract: Exportin 1 (XPO1/CRM1) is a key nuclear transport receptor (karyopherin) responsible for the export of different cargo proteins out of the cell’s nucleus into the cytoplasm. Its correct function is essential for cellular homeostasis, however… read more here.
Keywords: function; xpo1; inhibitor; efficacy ... See more keywords
Prognostic impact of XPO1 mutations in metastatic non-small cell lung cancer (NSCLC).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e20533
Abstract: e20533 Background: Nuclear protein transport is essential in guiding the organized traffic of important proteins and RNAs between the nucleus and cytoplasm of the cell. Export of proteins from the nucleus is exclusively regulated by… read more here.
Keywords: histology; xpo1 mutations; impact xpo1; xpo1 mutant ... See more keywords
Selinexor and COVID-19: The Neglected Warden
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DOI: 10.3389/fphar.2022.884228
Abstract: A novel severe acute respiratory distress syndrome coronavirus type 2 (SARS-CoV-2) has been confirmed as the cause of the global pandemic coronavirus disease 2019 (COVID-19). Different repurposed drugs have been trialed and used in the… read more here.
Keywords: xpo1; covid; sxr; selinexor covid ... See more keywords
Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance
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DOI: 10.3390/cancers11040479
Abstract: A majority of breast cancer specific deaths in women with ERα (+) tumors occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent… read more here.
Keywords: akt; combined targeting; metabolic pathways; resistance ... See more keywords
Targeting Nuclear Exporter Protein XPO1/CRM1 in Gastric Cancer
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DOI: 10.3390/ijms20194826
Abstract: Gastric cancer remains an unmet clinical problem in urgent need of newer and effective treatments. Here we show that the nuclear export protein, Exportin 1 (XPO1, chromosome region maintenance 1 or CRM1), is a promising… read more here.
Keywords: protein; sine compounds; gastric cancer; cancer ... See more keywords
Identification of Novel Covalent XPO1 Inhibitors Based on a Hybrid Virtual Screening Strategy
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DOI: 10.3390/molecules27082543
Abstract: Nuclear export protein 1 (XPO1), a member of the nuclear export protein-p (Karyopherin-P) superfamily, regulates the transport of “cargo” proteins. To facilitate this important process, which is essential for cellular homeostasis, XPO1 must first recognize… read more here.
Keywords: xpo1; hybrid virtual; virtual screening; covalent ... See more keywords