Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202412096
Abstract: Basal‐like breast cancer (BLBC), overlapping with the subgroup of estrogen receptor (ER), progesterone receptor (PR), and HER2 triple‐negative breast cancer, has the worst prognosis and limited therapeutics. The XPO1 gene encodes nuclear export protein 1,… read more here.
Keywords: xpo1; breast cancer; regulation; feedback ... See more keywords
Inhibition of XPO1 impairs cholangiocarcinoma cell proliferation by triggering p53 intranuclear accumulation
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5322
Abstract: XPO1 mediates the nuclear export of several proteins, mainly tumor suppressors. KPT‐330 (Selinexor) is a selective inhibitor of XPO1 that has demonstrated good therapeutic effects in hematologic cancers. read more here.
Keywords: cell proliferation; xpo1; cholangiocarcinoma cell; inhibition xpo1 ... See more keywords
Prognostic and functional role of the nuclear export receptor 1 (XPO1) in gastrointestinal cancers: a potential novel target?
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Biology Reports"
DOI: 10.1007/s11033-024-10169-5
Abstract: In the last decades the survival of metastatic gastrointestinal (GI) cancer patients could have been significantly extended due to the introduction of targeted- and immunotherapy. However, only the minority of patients will experience long-lasting survival.… read more here.
Keywords: nuclear export; cancer; role; cancer patients ... See more keywords
XPO1 Gene Therapy Attenuates Cardiac Dysfunction in Rats with Chronic Induced Myocardial Infarction
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cardiovascular Translational Research"
DOI: 10.1007/s12265-019-09932-y
Abstract: Transcriptomic signature of XPO1 was highly expressed and inversely related to left ventricular function in ischemic cardiomyopathy patients. We hypothesized that treatment with AAV9-shXPO1 attenuates left ventricular dysfunction and remodeling in a myocardial infarction rat… read more here.
Keywords: aav9 shxpo1; dysfunction; myocardial infarction; left ventricular ... See more keywords
Proteomics identify nuclear export as a targetable pathway in neuroblastoma: Comment on “XPO1 inhibition with selinexor synergizes with proteasome inhibition in neuroblastoma by targeting nuclear export of IκB”
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101150
Abstract: Neuroblastoma (NBL) is an embryonal malignancy of childhood with poor outcomes for patient with high-risk disease. Multimodal treatment approaches have improved outcomes but at the cost of significant toxicity, and there is no durable therapeutic… read more here.
Keywords: export; nuclear export; inhibition; identify nuclear ... See more keywords
XPO1-Targeting Selective Inhibitors of Transcriptional Activation Suppress Graft-versus-Host Disease.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00989
Abstract: Exportin-1 (XPO1) is a mediator of nuclear-to-cytoplasmic protein trafficking. The XPO1-targeting selective inhibitor of nuclear export (SINE) Selinexor is FDA-approved for relapsed hematological malignancies. Recently, we reported a unique class of XPO1 modulators that suppressed… read more here.
Keywords: targeting selective; selective inhibitors; activation; xpo1 targeting ... See more keywords
The nuclear export protein XPO1 — from biology to targeted therapy
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Clinical Oncology"
DOI: 10.1038/s41571-020-00442-4
Abstract: Exportin 1 (XPO1), also known as chromosome region maintenance protein 1, plays a crucial role in maintaining cellular homeostasis via the regulated export of a range of cargoes, including proteins and several classes of RNAs,… read more here.
Keywords: protein; export; nuclear export; biology ... See more keywords
XPO1R749Q Mutations Co-occur with POLE Mutations in Cancer and can be Targeted to Overcome Chemoresistance.
Sign Up to like & getrecommendations! Published in 2025 at "Cancer research"
DOI: 10.1158/0008-5472.can-24-3112
Abstract: XPO1 is a nuclear export receptor that is essential for cell survival. Previous genomic analyses have identified recurrent XPO1 hotspot mutations in cancer. Here, we conducted a large-scale genomic analysis of 217,570 cancer patients to… read more here.
Keywords: cancer; xpo1r749q mutations; mutations cancer; pole mutations ... See more keywords
Abstract 464: Novel role of xpo1 in regulating MicroRNAs related to pancreatic ductal adenocarcinoma invasion and metastasis
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-464
Abstract: Objective: There are no known reports on the role of exportin 1 (XPO1; also known as chromosome maintenance region 1 [CRM1]) in microRNA biology. In this study, we for the first time demonstrate that interfering… read more here.
Keywords: ductal adenocarcinoma; mir 145; invasion; pancreatic ductal ... See more keywords
Abstract 1652: A novel reversible inhibitor of XPO1 with potent efficacy in multiple preclinical mouse models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1652
Abstract: Exportin 1 (XPO1/CRM1) is a key nuclear transport receptor (karyopherin) responsible for the export of different cargo proteins out of the cell’s nucleus into the cytoplasm. Its correct function is essential for cellular homeostasis, however… read more here.
Keywords: function; xpo1; inhibitor; efficacy ... See more keywords
Abstract 2358: XPO1 inhibition serves as an effective chemoprevention strategy in colorectal cancer mouse models
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-2358
Abstract: Familial Adenomatous Polyposis (FAP) is a hereditary condition resulting in a 100% chance of developing colorectal cancer (CRC) if left untreated. Individuals with FAP often undergo colectomies in their 20s. Thus, there is a critical… read more here.
Keywords: cancer; xpo1 inhibition; chemoprevention; xpo1 ... See more keywords