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Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-19-0977
Abstract: XPO1 inhibitors have shown promise in cancer treatment, but mechanisms of resistance to these drugs are not well understood. In this study, we established selective inhibitors of nuclear export (SINE)-resistant ovarian cancer cell lines from…
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Keywords:
xpo1 inhibitors;
nrg1 erbb3;
cancer;
resistance ... See more keywords
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2
Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13010111
Abstract: Exportin-1 (XPO1) is a key player in the nuclear export pathway and is overexpressed in almost all cancers. This is especially relevant for non-Hodgkin lymphoma (NHL), where high XPO1 expression is associated with poor prognosis…
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Keywords:
hodgkin lymphoma;
non hodgkin;
lymphoma;
nuclear export ... See more keywords
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1
Published in 2022 at "Molecules"
DOI: 10.3390/molecules27082543
Abstract: Nuclear export protein 1 (XPO1), a member of the nuclear export protein-p (Karyopherin-P) superfamily, regulates the transport of “cargo” proteins. To facilitate this important process, which is essential for cellular homeostasis, XPO1 must first recognize…
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Keywords:
xpo1;
hybrid virtual;
virtual screening;
covalent ... See more keywords