NRG1/ERBB3 Pathway Activation Induces Acquired Resistance to XPO1 Inhibitors
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DOI: 10.1158/1535-7163.mct-19-0977
Abstract: XPO1 inhibitors have shown promise in cancer treatment, but mechanisms of resistance to these drugs are not well understood. In this study, we established selective inhibitors of nuclear export (SINE)-resistant ovarian cancer cell lines from… read more here.
Keywords: xpo1 inhibitors; nrg1 erbb3; cancer; resistance ... See more keywords
Nuclear Export in Non-Hodgkin Lymphoma and Implications for Targeted XPO1 Inhibitors
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DOI: 10.3390/biom13010111
Abstract: Exportin-1 (XPO1) is a key player in the nuclear export pathway and is overexpressed in almost all cancers. This is especially relevant for non-Hodgkin lymphoma (NHL), where high XPO1 expression is associated with poor prognosis… read more here.
Keywords: hodgkin lymphoma; non hodgkin; lymphoma; nuclear export ... See more keywords
Identification of Novel Covalent XPO1 Inhibitors Based on a Hybrid Virtual Screening Strategy
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DOI: 10.3390/molecules27082543
Abstract: Nuclear export protein 1 (XPO1), a member of the nuclear export protein-p (Karyopherin-P) superfamily, regulates the transport of “cargo” proteins. To facilitate this important process, which is essential for cellular homeostasis, XPO1 must first recognize… read more here.
Keywords: xpo1; hybrid virtual; virtual screening; covalent ... See more keywords