XPO1-Targeting Selective Inhibitors of Transcriptional Activation Suppress Graft-versus-Host Disease.
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DOI: 10.1021/acs.jmedchem.5c00989
Abstract: Exportin-1 (XPO1) is a mediator of nuclear-to-cytoplasmic protein trafficking. The XPO1-targeting selective inhibitor of nuclear export (SINE) Selinexor is FDA-approved for relapsed hematological malignancies. Recently, we reported a unique class of XPO1 modulators that suppressed… read more here.
Keywords: targeting selective; selective inhibitors; activation; xpo1 targeting ... See more keywords