Abstract 2976: XPR1 and SLC34A2 (NaPi2B)- A tale of targeting the phosphate homeostasis in cancer cells
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DOI: 10.1158/1538-7445.am2025-2976
Abstract: SLC34A2 is overexpressed in 61% of ovarian cancer and 18% of uterine cancer tumors. SLC34A2 overexpression is believed to be driven by the aberrant activity of the essential PAX8 transcription factor in these tumors. Overexpression… read more here.
Keywords: cancer; cancer cells; inhibition; xpr1 ... See more keywords
In-depth evaluation of XPR1 as a new prognostic indicator for endometrial cancer
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DOI: 10.1186/s12885-025-14818-1
Abstract: XPR1 is crucial in the development of some tumors, yet its association with endometrial cancer (EC) remains uncertain. We propose that XPR1 exhibits elevated expression in EC and is significantly linked to unfavorable patient outcomes,… read more here.
Keywords: prognostic indicator; xpr1; endometrial cancer; xpr1 expression ... See more keywords
XPR1 Mediates the Pancreatic β-Cell Phosphate Flush
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DOI: 10.2337/db19-0633
Abstract: Glucose-stimulated insulin secretion is the hallmark of the pancreatic β-cell, a critical player in the regulation of blood glucose concentration. In 1974, the remarkable observation was made that an efflux of intracellular inorganic phosphate (Pi)… read more here.
Keywords: secretion; xpr1; phosphate flush; cell ... See more keywords