Radio‐adaptive response, individual radio‐sensitivity and correlation of base excision repair gene polymorphism (hOGG1, APE1, XRCC1, and LIGASE1) in human peripheral blood mononuclear cells exposed to gamma radiation
Sign Up to like & getrecommendations! Published in 2020 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22383
Abstract: Radio‐adaptive response (RAR) is a biological mechanism, where cells primed with a low dose exhibit reduced DNA damage with a high challenging dose. Single nucleotide polymorphisms (SNPs) of DNA repair genes including base excision repair… read more here.
Keywords: ligase1; radio; radio sensitivity; xrcc1 ... See more keywords
Hemoglobin level and XRCC1 polymorphisms to select patients with locally advanced rectal cancer candidate for neoadjuvant chemoradiotherapy with concurrent capecitabine and a platinum salt
Sign Up to like & getrecommendations! Published in 2018 at "Medical Oncology"
DOI: 10.1007/s12032-018-1141-4
Abstract: A platinum salt (oxaliplatin or cisplatin) is widely used to enhance chemoradation (CRT) response. The potential of cisplatin in neoadjuvant CRT for locally advanced rectal cancer (LARC) has not been fully investigated. Consecutive patients with… read more here.
Keywords: response; ajcc grade; locally advanced; platinum salt ... See more keywords
XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity.
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DOI: 10.1016/j.dnarep.2018.02.004
Abstract: Aprataxin (APTX) is a DNA-adenylate hydrolase that removes 5'-AMP blocking groups from abortive ligation repair intermediates. XRCC1, a multi-domain protein without catalytic activity, interacts with a number of known repair proteins including APTX, modulating and… read more here.
Keywords: dna; xrcc1 phosphorylation; activity; xrcc1 ... See more keywords
Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage
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DOI: 10.1038/s41598-019-39543-1
Abstract: Repair of two major forms of DNA damage, single strand breaks and base modifications, are dependent on XRCC1. XRCC1 orchestrates these repair processes by temporally and spatially coordinating interactions between several other repair proteins. Here… read more here.
Keywords: dna damage; dna; damage; dna binding ... See more keywords
Polymorphisms of DNA repair genes XRCC1 and LIG4 and idiopathic male infertility
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DOI: 10.1080/19396368.2017.1374488
Abstract: ABSTRACT Sperm DNA damage is one of the associated factors of idiopathic male infertility and abnormal spermatogenesis. This study was conducted to assess possible association between risk of male infertility with X-ray repair cross complementing… read more here.
Keywords: risk; lig4; male infertility; infertility ... See more keywords
Characterization of the APLF FHA–XRCC1 phosphopeptide interaction and its structural and functional implications
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DOI: 10.1093/nar/gkx941
Abstract: Abstract Aprataxin and PNKP-like factor (APLF) is a DNA repair factor containing a forkhead-associated (FHA) domain that supports binding to the phosphorylated FHA domain binding motifs (FBMs) in XRCC1 and XRCC4. We have characterized the… read more here.
Keywords: fha domain; aplf fha; interaction; xrcc1 ... See more keywords
Ibrutinib provides favourable survival outcomes in patients with comorbidities versus established therapies
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Haematology"
DOI: 10.1111/bjh.15784
Abstract: Abdel-Rahman, S.Z. & El-Zein, R.A. (2000) The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobaccospecific nitrosamine NNK. Cancer Letters, 159, 63–71. Bravard, A., Vacher,… read more here.
Keywords: cancer; dna repair; xrcc1; polymorphism ... See more keywords
Targeting PARP1 in XRCC1-Deficient Sporadic Invasive Breast Cancer or Preinvasive Ductal Carcinoma In Situ Induces Synthetic Lethality and Chemoprevention.
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DOI: 10.1158/0008-5472.can-18-0633
Abstract: : Targeting PARP1 for synthetic lethality is a new strategy for breast cancers harboring germline mutations in BRCA. However, these mutations are rare, and reactivation of BRCA-mediated pathways may result in eventual resistance to PARP1… read more here.
Keywords: synthetic lethality; xrcc1 deficient; xrcc1; breast ... See more keywords
MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia
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DOI: 10.1186/s12885-020-06749-w
Abstract: Background Despite conflicting results, considerable evidence suggests the association between single nucleotide polymorphisms in MTHFR , XRCC1 and OGG1 genes and, risk of developing breast cancer. Here a case-control study is reported, including 135 breat… read more here.
Keywords: study; breast cancer; cancer; xrcc1 ... See more keywords
Association of base excision repair pathway genes OGG1, XRCC1 and MUTYH polymorphisms and the level of 8-oxo-guanine with increased risk of colorectal cancer occurrence.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of occupational medicine and environmental health"
DOI: 10.13075/ijomeh.1896.01901
Abstract: OBJECTIVES Reduced efficiency of DNA repair systems has long been a suspected factor in increasing the risk of cancer. In this work authors investigate influence of selected polymorphisms of DNA repair genes (XRCC1, OGG1 and… read more here.
Keywords: xrcc1; mutyh; risk; colorectal cancer ... See more keywords
XRCC1 serves as a potential prognostic indicator for clear cell renal cell carcinoma and inhibits its invasion and metastasis through suppressing MMP-2 and MMP-9
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DOI: 10.18632/oncotarget.22680
Abstract: X-ray repair cross-complementing group 1 (XRCC1) is a major DNA repair gene that is responsible for fixing DNA base damage and single-strand breaks by interacting with DNA components at the damage site. This study explored… read more here.
Keywords: ccrcc; metastasis; expression; cell ... See more keywords