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   Articles with "xrcc1" as a keyword



Radio‐adaptive response, individual radio‐sensitivity and correlation of base excision repair gene polymorphism (hOGG1, APE1, XRCC1, and LIGASE1) in human peripheral blood mononuclear cells exposed to gamma radiation

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recommendations! Published in 2020 at "Environmental and Molecular Mutagenesis"

DOI: 10.1002/em.22383

Abstract: Radio‐adaptive response (RAR) is a biological mechanism, where cells primed with a low dose exhibit reduced DNA damage with a high challenging dose. Single nucleotide polymorphisms (SNPs) of DNA repair genes including base excision repair… read more here.

Keywords: ligase1; radio; radio sensitivity; xrcc1 ... See more keywords

Hemoglobin level and XRCC1 polymorphisms to select patients with locally advanced rectal cancer candidate for neoadjuvant chemoradiotherapy with concurrent capecitabine and a platinum salt

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recommendations! Published in 2018 at "Medical Oncology"

DOI: 10.1007/s12032-018-1141-4

Abstract: A platinum salt (oxaliplatin or cisplatin) is widely used to enhance chemoradation (CRT) response. The potential of cisplatin in neoadjuvant CRT for locally advanced rectal cancer (LARC) has not been fully investigated. Consecutive patients with… read more here.

Keywords: response; ajcc grade; locally advanced; platinum salt ... See more keywords

XRCC1 phosphorylation affects aprataxin recruitment and DNA deadenylation activity.

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recommendations! Published in 2018 at "DNA repair"

DOI: 10.1016/j.dnarep.2018.02.004

Abstract: Aprataxin (APTX) is a DNA-adenylate hydrolase that removes 5'-AMP blocking groups from abortive ligation repair intermediates. XRCC1, a multi-domain protein without catalytic activity, interacts with a number of known repair proteins including APTX, modulating and… read more here.

Keywords: dna; xrcc1 phosphorylation; activity; xrcc1 ... See more keywords

Identification of an XRCC1 DNA binding activity essential for retention at sites of DNA damage

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-39543-1

Abstract: Repair of two major forms of DNA damage, single strand breaks and base modifications, are dependent on XRCC1. XRCC1 orchestrates these repair processes by temporally and spatially coordinating interactions between several other repair proteins. Here… read more here.

Keywords: dna damage; dna; damage; dna binding ... See more keywords

Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-01870-x

Abstract: Defects in DNA single-strand break repair are associated with neurodevelopmental and neurodegenerative disorders. One such disorder is that resulting from mutations in XRCC1, a scaffold protein that plays a central role in DNA single-strand base… read more here.

Keywords: rescues cerebellar; xrcc1; zebrafish; xrcc1 mutant ... See more keywords

Polymorphisms of DNA repair genes XRCC1 and LIG4 and idiopathic male infertility

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recommendations! Published in 2017 at "Systems Biology in Reproductive Medicine"

DOI: 10.1080/19396368.2017.1374488

Abstract: ABSTRACT Sperm DNA damage is one of the associated factors of idiopathic male infertility and abnormal spermatogenesis. This study was conducted to assess possible association between risk of male infertility with X-ray repair cross complementing… read more here.

Keywords: risk; lig4; male infertility; infertility ... See more keywords

Characterization of the APLF FHA–XRCC1 phosphopeptide interaction and its structural and functional implications

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recommendations! Published in 2017 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkx941

Abstract: Abstract Aprataxin and PNKP-like factor (APLF) is a DNA repair factor containing a forkhead-associated (FHA) domain that supports binding to the phosphorylated FHA domain binding motifs (FBMs) in XRCC1 and XRCC4. We have characterized the… read more here.

Keywords: fha domain; aplf fha; interaction; xrcc1 ... See more keywords

Ibrutinib provides favourable survival outcomes in patients with comorbidities versus established therapies

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recommendations! Published in 2019 at "British Journal of Haematology"

DOI: 10.1111/bjh.15784

Abstract: Abdel-Rahman, S.Z. & El-Zein, R.A. (2000) The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobaccospecific nitrosamine NNK. Cancer Letters, 159, 63–71. Bravard, A., Vacher,… read more here.

Keywords: cancer; dna repair; xrcc1; polymorphism ... See more keywords

Targeting PARP1 in XRCC1-Deficient Sporadic Invasive Breast Cancer or Preinvasive Ductal Carcinoma In Situ Induces Synthetic Lethality and Chemoprevention.

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recommendations! Published in 2018 at "Cancer research"

DOI: 10.1158/0008-5472.can-18-0633

Abstract: : Targeting PARP1 for synthetic lethality is a new strategy for breast cancers harboring germline mutations in BRCA. However, these mutations are rare, and reactivation of BRCA-mediated pathways may result in eventual resistance to PARP1… read more here.

Keywords: synthetic lethality; xrcc1 deficient; xrcc1; breast ... See more keywords

Abstract 6103: The association of genetic polymorphisms in DNA repair genes XRCC1 and 3 with cervical cancer risk among Bangladeshi females

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-6103

Abstract: Introduction and Objective: Worldwide, cervical cancer ranks the second most common cancer in women. Sequence variations in DNA repair genes X-ray repair cross complementing (XRCC) 1 and 3 genes can lead to can result cellular… read more here.

Keywords: cancer; risk; cervical cancer; repair ... See more keywords

MTHFR, XRCC1 and OGG1 genetic polymorphisms in breast cancer: a case-control study in a population from North Sardinia

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recommendations! Published in 2020 at "BMC Cancer"

DOI: 10.1186/s12885-020-06749-w

Abstract: Background Despite conflicting results, considerable evidence suggests the association between single nucleotide polymorphisms in MTHFR , XRCC1 and OGG1 genes and, risk of developing breast cancer. Here a case-control study is reported, including 135 breat… read more here.

Keywords: study; breast cancer; cancer; xrcc1 ... See more keywords