Targeting PARP1 in XRCC1-Deficient Sporadic Invasive Breast Cancer or Preinvasive Ductal Carcinoma In Situ Induces Synthetic Lethality and Chemoprevention.
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DOI: 10.1158/0008-5472.can-18-0633
Abstract: : Targeting PARP1 for synthetic lethality is a new strategy for breast cancers harboring germline mutations in BRCA. However, these mutations are rare, and reactivation of BRCA-mediated pathways may result in eventual resistance to PARP1… read more here.
Keywords: synthetic lethality; xrcc1 deficient; xrcc1; breast ... See more keywords