Feline XRCC4 undergoes rapid Ku‐dependent recruitment to DNA damage sites
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DOI: 10.1002/2211-5463.13363
Abstract: Radiation and chemotherapy resistance remain some of the greatest challenges in human and veterinary cancer therapies. XRCC4, an essential molecule for nonhomologous end joining repair, is a promising target for radiosensitizers. Genetic variants and mutations… read more here.
Keywords: dna; localization; xrcc4; xrcc4 undergoes ... See more keywords
Structural study of wild-type and phospho-mimic XRCC4 dimer and multimer proteins using circular dichroism spectroscopy.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of radiation biology"
DOI: 10.1080/09553002.2023.2214210
Abstract: PURPOSE To investigate the structural features of wild-type and phospho-mimicking mutated XRCC4 protein, a protein involved in DNA double-strand break repair. MATERIALS AND METHODS XRCC4 with a HisTag were expressed by E. coli harboring plasmid… read more here.
Keywords: phospho mimic; xrcc4; spectroscopy; type phospho ... See more keywords
APTX acts in DNA double-strand break repair in a manner distinct from XRCC4
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DOI: 10.1093/jrr/rrad007
Abstract: Abstract Aprataxin (APTX), the product of the causative gene for hereditary neurogenerative syndromes Ataxia-oculomotor apraxia 1 and early onset ataxia with oculomotor apraxia and hypoalbuminemia, has an enzymatic activity of removing adenosine monophosphate from DNA… read more here.
Keywords: aptx; xrcc4; strand break; break repair ... See more keywords
Dysregulation of X-Ray Repair Cross Complementing 4 Expression in the Eutopic Endometrium of Women with Endometriosis.
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DOI: 10.1530/rep-21-0436
Abstract: Recent data suggest that the DNA damage response (DDR) is altered in the eutopic endometrium (EE) of women with endometriosis and this probably ensues in response to higher DNA damage encountered by the EE in… read more here.
Keywords: endometriosis; women endometriosis; xrcc4; eutopic endometrium ... See more keywords
Platinum-Resistant Ovarian Cancer Is Vulnerable to the cJUN-XRCC4 Pathway Inhibition
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DOI: 10.3390/cancers14246068
Abstract: Simple Summary Although the initial clinical response of ovarian cancer patients to first-line platinum-based chemotherapy is often excellent, most patients relapse and develop resistance to treatment. However, the mechanism underlying resistance is unclear. DNA repair… read more here.
Keywords: xrcc4; platinum resistance; ovarian cancer; cancer ... See more keywords