Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04606-z
Abstract: The aim of this study was to evaluate whether Gemin 5, Cpeb, Xrn1, and Stau1 expression in rodent ovaries and uterine tissues is dependent on gonadotropins, steroid hormones, and leptin in the superovulation and ovariectomized… read more here.
Keywords: gemin; expression; cpeb; estradiol leptin ... See more keywords
Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis
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DOI: 10.1016/j.isci.2021.103151
Abstract: Summary Control of mRNA stability and degradation is essential for appropriate gene expression, and its dysregulation causes various disorders, including cancer, neurodegenerative diseases, diabetes, and obesity. The 5′–3′ exoribonuclease XRN1 executes the last step of… read more here.
Keywords: metabolic homeostasis; maintenance; mice; xrn1 cko ... See more keywords
Engineered viral RNA decay intermediates to assess XRN1-mediated decay.
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DOI: 10.1016/j.ymeth.2018.11.019
Abstract: Both RNA synthesis and decay must be balanced within a cell to achieve proper gene expression. Additionally, modulation of RNA decay specifically offers the cell an opportunity to rapidly reshape the transcriptome in response to… read more here.
Keywords: mediated decay; rna; rna decay; biologically relevant ... See more keywords
Recruitment of Xrn1 to stress-induced genes allows efficient transcription by controlling RNA polymerase II backtracking
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DOI: 10.1080/15476286.2020.1857521
Abstract: ABSTRACT A new paradigm has emerged proposing that the crosstalk between nuclear transcription and cytoplasmic mRNA stability keeps robust mRNA levels in cells under steady-state conditions. A key piece in this crosstalk is the highly… read more here.
Keywords: transcription; rna polymerase; stress; induced genes ... See more keywords
Endogenous RNAi pathway evolutionarily shapes the destiny of the antisense lncRNAs transcriptome
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DOI: 10.26508/lsa.201900407
Abstract: A genome-wide comparative analysis of “cryptic” aslncRNAs decay in RNAi-capable and RNAi-deficient budding yeasts suggests an evolutionary contribution of RNAi in shaping the aslncRNAs transcriptome. Antisense long noncoding (aslnc)RNAs are extensively degraded by the nuclear… read more here.
Keywords: antisense; rnai pathway; endogenous rnai; rnai ... See more keywords