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   Articles with "xrn2" as a keyword



XRN2 promotes EMT and metastasis through regulating maturation of miR-10a

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recommendations! Published in 2017 at "Oncogene"

DOI: 10.1038/onc.2017.39

Abstract: MicroRNAs (miRNAs) have been proposed as critical regulatory molecules in the epithelial–mesenchymal transition (EMT) program. However, the roles of mature miRNA biogenesis during EMT process needs to be defined. Here we determined that increased expression… read more here.

Keywords: xrn2; metastasis; xrn2 promotes; promotes emt ... See more keywords
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XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition

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recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-71203-7

Abstract: Persistent R-loops (RNA–DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5′-3′-exoribonuclease 2 (XRN2) degrades RNA to resolve R-loops and promotes transcription termination. Previously, XRN2 was implicated in… read more here.

Keywords: xrn2; parp1 inhibition; repair; dna ... See more keywords

The human HELQ helicase and XRN2 exoribonuclease cooperate in R-loop resolution

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recommendations! Published in 2025 at "Open Biology"

DOI: 10.1098/rsob.240112

Abstract: The human HELQ helicase is a superfamily 2, 3′-5 helicase homologous to POLQ and RNA helicases of the Ski2-like subfamily. It is involved in diverse aspects of DNA repair and is an emerging prognosis biomarker… read more here.

Keywords: helq helicase; helq; loop resolution; helicase ... See more keywords

Oncogene 5’-3’ exoribonuclease 2 enhances epidermal growth factor receptor signaling pathway to promote epithelial–mesenchymal transition and metastasis in non-small-cell lung cancer

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recommendations! Published in 2024 at "CytoJournal"

DOI: 10.25259/cytojournal_49_2024

Abstract: Objective: Epithelial–mesenchymal transition (EMT) and metastasis are the primary causes of mortality in non-small-cell lung cancer (NSCLC). 5’-3’ exoribonuclease 2 (XRN2) plays an important role in the process of tumor EMT. Thus, this investigation mainly… read more here.

Keywords: xrn2 xrn2; xrn2 egfr; cell; metastasis ... See more keywords