XRN2 promotes EMT and metastasis through regulating maturation of miR-10a
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DOI: 10.1038/onc.2017.39
Abstract: MicroRNAs (miRNAs) have been proposed as critical regulatory molecules in the epithelial–mesenchymal transition (EMT) program. However, the roles of mature miRNA biogenesis during EMT process needs to be defined. Here we determined that increased expression… read more here.
Keywords: xrn2; metastasis; xrn2 promotes; promotes emt ... See more keywords
XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition
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DOI: 10.1038/s41598-020-71203-7
Abstract: Persistent R-loops (RNA–DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5′-3′-exoribonuclease 2 (XRN2) degrades RNA to resolve R-loops and promotes transcription termination. Previously, XRN2 was implicated in… read more here.
Keywords: xrn2; parp1 inhibition; repair; dna ... See more keywords