Crystal structure of a xylulose 5-phosphate phosphoketolase. Insights into the substrate specificity for xylulose 5-phosphate.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2019.04.017
Abstract: Phosphoketolases (PK) are TPP-dependent enzymes which play essential roles in carbohydrate metabolism of numerous bacteria. Depending on the substrate specificity PKs can be subdivided into xylulose 5-phosphate (X5P) specific PKs (XPKs) and PKs which accept… read more here.
Keywords: pks; x5p; xylulose phosphate; structure ... See more keywords
Antibacterial Target DXP Synthase Catalyzes the Cleavage of d-Xylulose 5-Phosphate: a Study of Ketose Phosphate Binding and Ketol Transfer Reaction.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00274
Abstract: The bacterial enzyme 1-deoxy-d-xylulose 5-phosphate synthase (DXPS) catalyzes the formation of DXP from pyruvate and d-glyceraldehyde 3-phosphate (d-GAP) in a thiamin diphosphate (ThDP)-dependent manner. In addition to its role in isoprenoid biosynthesis, DXP is required… read more here.
Keywords: phosphate; synthase; dxps; donor ... See more keywords
High Yield of Bioactive Abietane Diterpenes in Salvia sclarea Hairy Roots by Overexpressing Cyanobacterial DXS or DXR Genes.
Sign Up to like & getrecommendations! Published in 2019 at "Planta medica"
DOI: 10.1055/a-0895-5878
Abstract: Abietane diterpenoids, containing a quinone moiety, are synthesized in the roots of several Salvia species. Promising cytotoxicity and antiproliferative activities have been reported for these compounds in various cell and animal models. We have recently… read more here.
Keywords: hairy roots; deoxy xylulose; abietane; xylulose phosphate ... See more keywords
A paradigm towards the antimalarial quest: in silico identification and biological evaluation of novel inhibitors targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1570342
Abstract: 1-deoxy-D-xylulose-5-phosphate reductoisomerase, catalyzing the rate-limiting step of the isoprenoid synthesis pathway in the malaria parasite, is accredited as a potential drug target. In the present study, a structure based computational approach and biological evaluation were… read more here.
Keywords: deoxy xylulose; biological evaluation; phosphate reductoisomerase; xylulose phosphate ... See more keywords
Cloning, characterization, and expression of 1-deoxy-D-xylulose-5-phosphate reductoisomerase gene from Dioscorea zingiberensis
Sign Up to like & getrecommendations! Published in 2019 at "Biologia plantarum"
DOI: 10.32615/bp.2019.030
Abstract: Diosgenin, mainly extracted from some Dioscorea species, is the most important starting material for the production of steroidal drugs. It is believed that diosgenin in Dioscorea is synthesized from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate… read more here.
Keywords: expression; deoxy xylulose; mep pathway; zingiberensis ... See more keywords
Functional Characterization of the 1-Deoxy-D-Xylulose 5-Phosphate Synthase Genes in Morus notabilis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.01142
Abstract: Terpenoids are considered to be the largest group of secondary metabolites and natural products. Studies have revealed 1-deoxy-D-xylulose 5-phosphate synthase (DXS) is the first and rate-limiting enzyme in the plastidial methylerythritol phosphate pathway, which produces… read more here.
Keywords: morus notabilis; deoxy xylulose; xylulose phosphate; phosphate synthase ... See more keywords
Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate
Sign Up to like & getrecommendations! Published in 2023 at "Crystals"
DOI: 10.3390/cryst13050737
Abstract: Stagnation in the development of new antibiotics emphasizes the need for the discovery of drugs with novel modes of action that can tackle antibiotic resistance. Contrary to humans, most bacteria use the methylerythritol phosphate (MEP)… read more here.
Keywords: phosphate; structure; tuberculosis; deoxy xylulose ... See more keywords