Estrogen-independent Myc overexpression confers endocrine therapy resistance on breast cancer cells expressing ERαY537S and ERαD538G mutations.
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DOI: 10.1016/j.canlet.2018.10.041
Abstract: Approximately 30% of metastatic breast cancers harbor estrogen receptor α (ERα) mutations associated with resistance to endocrine therapy and reduced survival. Consistent with their constitutive proliferation, T47D and MCF7 cells in which wild-type ERα is… read more here.
Keywords: endocrine therapy; breast; mutant cells; y537s d538g ... See more keywords