p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.03.051
Abstract: Huntington's disease (HD) is a hereditary neurodegenerative disorder resulting from N-terminal polyglutamine expansion in the huntingtin protein. A relatively selective and early loss of medium spiny neurons in the striatum is a hallmark of HD… read more here.
Keywords: yac128 mouse; huntington disease; p35; mouse model ... See more keywords
Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington's Disease
Sign Up to like & getrecommendations! Published in 2018 at "Neural Plasticity"
DOI: 10.1155/2018/4056383
Abstract: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a trinucleotide expansion in the HD gene, resulting in an extended polyglutamine tract in the protein huntingtin. HD is traditionally viewed as a movement… read more here.
Keywords: huntington disease; symptomatic yac128; yac128; yac128 transgenic ... See more keywords