p35 hemizygosity activates Akt but does not improve motor function in the YAC128 mouse model of Huntington’s disease
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DOI: 10.1016/j.neuroscience.2017.03.051
Abstract: Huntington's disease (HD) is a hereditary neurodegenerative disorder resulting from N-terminal polyglutamine expansion in the huntingtin protein. A relatively selective and early loss of medium spiny neurons in the striatum is a hallmark of HD… read more here.
Keywords: yac128 mouse; huntington disease; p35; mouse model ... See more keywords