Integrated GC-MS and UHPLC-MS renal metabolomics and lipidomics deciphered the metabolic regulation mechanism of Gushudan on kidney-yang-deficiency-syndrome rats.
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DOI: 10.1002/jssc.202300124
Abstract: Kidney-yang-deficiency-syndrome is a neuroendocrine disease caused by the dysfunction of adrenal-pituitary-target gland axis. Gushudan is a traditional Chinese medicine prescription with functions of tonifying kidney and strengthening bone, and its bone-strengthening effect has been confirmed… read more here.
Keywords: deficiency syndrome; kidney; gushudan; yang deficiency ... See more keywords
Plasma metabolomics coupled with MetaboAnalyst and Ingenuity Pathway Analysis characterizes linoleic acid metabolism disorder in patients with spleen-yang-deficiency syndrome
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DOI: 10.1016/j.eujim.2018.02.007
Abstract: Abstract Introduction Spleen-yang-deficiency syndrome (SYDS) is a hot spot pattern in gastroenterology in traditional Chinese medicine (TCM) clinic and has received increasing attention from clinicians because it is closely related to diseases of diarrhoea, irritable… read more here.
Keywords: medicine; spleen yang; metabolism; linoleic acid ... See more keywords
1H NMR studies on serum metabonomic changes over time in a kidney-Yang deficiency syndrome model
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DOI: 10.1039/c7ra04057a
Abstract: The central aim of this study was to investigate metabolite changes in metabolic pathways via metabonomic approaches in rats suffering from Kidney-Yang Deficiency Syndrome (KYDS) induced by hydrocortisone. Metabonomic analysis using 1H NMR is a… read more here.
Keywords: kidney yang; metabolism; time; deficiency syndrome ... See more keywords
Kidney Yang Deficiency Syndrome Exacerbates Aβ25-35-Induced Pathological Changes, And Ginsenoside Re Ameliorates Synapse Lesions In Aβ25-35-Injected Rats With Kidney Yang Deficiency Syndrome.
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DOI: 10.2174/1567205020666230512094230
Abstract: BACKGROUND Traditional Chinese medicine (TCM) indicates that Alzheimer's disease (AD) is considered the consequence produced by Kidney Yang Deficiency Syndrome (KDS-Yang), which has similar clinical characteristics to glucocorticoid withdrawal syndrome. Ginsenoside Re (G-Re) has been… read more here.
Keywords: deficiency syndrome; syndrome; yang deficiency; deficiency ... See more keywords
Dysfunction of cecal microbiota and CutC activity in mice mediating diarrhea with kidney-yang deficiency syndrome
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DOI: 10.3389/fmicb.2024.1354823
Abstract: Objective Previous studies have indicated that diarrhea with kidney-yang deficiency syndrome leads to a disorder of small intestine contents and mucosal microbiota. However, the relationship of TMA-lyase (CutC) activity and TMAO with diarrhea with kidney-yang… read more here.
Keywords: yang deficiency; kidney yang; cutc activity; diarrhea kidney ... See more keywords
Association of intestinal mucosal barrier function with intestinal microbiota in Spleen-Kidney Yang Deficiency IBS-D mice
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DOI: 10.3389/fmicb.2025.1567971
Abstract: Background To establish and evaluate an IBS-D mouse model with Spleen-Kidney Yang Deficiency, explore the microecological mechanisms of IBS-D, and provide experimental evidence for the clinical diagnosis and treatment of IBS-D with Spleen-Kidney Yang Deficiency.… read more here.
Keywords: intestinal mucosal; yang deficiency; kidney yang; spleen kidney ... See more keywords
Characterization of the integrated gut microbiota and metabolite profiles in osteoporosis patients with different traditional Chinese medicine syndromes
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DOI: 10.3389/fmicb.2025.1663716
Abstract: Introduction This study aims to investigate whether the Traditional Chinese Medicine (TCM) classification of osteoporosis corresponds to specific gut microbial and metabolic profiles, thereby providing a microbiological basis for TCM syndrome differentiation. Methods Body composition… read more here.
Keywords: osteoporosis patients; gut microbiota; yang deficiency; medicine ... See more keywords