CCDC115 inhibits autophagy‐mediated degradation of YAP to promote cell proliferation
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14575
Abstract: Autophagy and Hippo signalling pathways both play important roles in cell homeostasis and are often involved in tumourigenesis. However, the crosstalk between these two signal pathways in response to stress conditions, such as nutrient deficiency,… read more here.
Keywords: cell proliferation; inhibits autophagy; yap; ccdc115 inhibits ... See more keywords
Transforming Growth Factor Beta Promotes Inflammation and Tumorigenesis in Smad4-Deficient Intestinal Epithelium in a YAP-Dependent Manner.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300708
Abstract: Transforming growth factor beta (TGF-β), a multifunctional cytokine, plays critical roles in immune responses. However, the precise role of TGF-β in colitis and colitis-associated cancer remains poorly defined. Here, it is demonstrated that TGF-β promotes… read more here.
Keywords: transforming growth; tumorigenesis; smad4 deficient; yap ... See more keywords
Silencing of YAP attenuates pericyte‐myofibroblast transition and subretinal fibrosis in experimental model of choroidal neovascularization
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11809
Abstract: Age‐related macular degeneration (AMD) is the main reason of irreversible vision loss in the elderly. The subretinal fibrosis subsequent to choroidal neovascularization (CNV) is an important feature in the late stage of wet AMD and… read more here.
Keywords: pericyte myofibroblast; subretinal fibrosis; cnv; choroidal neovascularization ... See more keywords
High mobility group protein B1 controls liver cancer initiation through yes‐associated protein ‐dependent aerobic glycolysis
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29663
Abstract: Emerging studies have suggested that the Hippo pathway is involved in the tumorigenesis of hepatocellular carcinoma (HCC). However, the key regulator of the Hippo pathway in liver tumor metabolic reprogramming remains elusive. Here, we provide… read more here.
Keywords: protein; glycolysis; hif1; yap ... See more keywords
Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation‐driven hepatocarcinogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32693
Abstract: Background and Aims: Gain‐of‐function (GOF) mutations of CTNNB1 and loss‐of‐function (LOF) mutations of AXIN1 are recurrent genetic alterations in hepatocellular carcinoma (HCC). We aim to investigate the functional contribution of Hippo/YAP/TAZ in GOF CTNNB1 or… read more here.
Keywords: hcc; yap taz; met sgaxin1; yap ... See more keywords
Identification, subcellular localization and functional comparison of novel Yap splicing isoforms in mouse embryonic stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "IUBMB life"
DOI: 10.1002/iub.2571
Abstract: Hippo signaling pathway is involved in many biological processes including the fate decision of embryonic stem cells (ESCs). Yes-associated protein (Yap) function as a key effector of Hippo pathway, but its role in ESCs is… read more here.
Keywords: isoforms mouse; self renewal; yap; embryonic stem ... See more keywords
Effect of titanium ions on the Hippo/YAP signaling pathway in regulating biological behaviors of MC3T3‐E1 osteoblasts
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3590
Abstract: Titanium (Ti) and its corresponding alloys have been widely applied in dental and orthopedic implants. Owing to abrasion and corrosion of implants in the unfavorable electrolytic aqueous environment of the host body, Ti ions could… read more here.
Keywords: effect; signaling pathway; titanium; yap ... See more keywords
Role of the Hippo‐YAP/NF‐κB signaling pathway crosstalk in regulating biological behaviors of macrophages under titanium ion exposure
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4065
Abstract: The presence of metal ions, such as titanium (Ti) ions, is toxic to adjacent tissues of implants. Indeed, Ti ions may induce an inflammatory response through the NF‐κB pathway, thus causing damage to soft and… read more here.
Keywords: pathway; ion exposure; yap; hippo yap ... See more keywords
Yes-associated protein activation potentiates glycogen synthase kinase-3 inhibitor-induced proliferation of neonatal cardiomyocytes and iPS cell-derived cardiomyocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30724
Abstract: Because mammalian cardiomyocytes largely cease to proliferate immediately after birth, the regenerative activity of the heart is limited. To date, much effort has been made to clarify the regulatory mechanism of cardiomyocyte proliferation because the… read more here.
Keywords: activation; yap; proliferation; induced proliferation ... See more keywords
Obesity‐mediated upregulation of the YAP/IL33 signaling axis promotes aggressiveness and induces an immunosuppressive tumor microenvironment in breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30985
Abstract: Obesity is a well‐known risk factor for breast cancer formation and is associated with elevated mortality and a poor prognosis. An obesity‐mediated inflammatory microenvironment is conducive to the malignant progression of tumors. However, the detailed… read more here.
Keywords: obesity; breast cancer; il33; yap ... See more keywords
N‐terminal β‐strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor
Sign Up to like & getrecommendations! Published in 2023 at "Protein Science"
DOI: 10.1002/pro.4545
Abstract: The yes‐associated protein (YAP) regulates the transcriptional activity of the TEAD transcription factors that are key in the control of organ morphogenesis. YAP interacts with TEAD via three secondary structure elements: a β‐strand, an α‐helix,… read more here.
Keywords: binding; strand; affinity; tead transcription ... See more keywords