Yap-Sox9 signaling determines hepatocyte plasticity and lineage-specific hepatocarcinogenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2021.11.010
Abstract: BACKGROUND & AIMS Primary liver tumors contain distinct subtypes. A subset of iCCAs can arise from cell fate reprogramming of mature hepatocytes in mouse models. However, the underpinning of cell fate plasticity during hepatocarcinogenesis is… read more here.
Keywords: hepatocarcinogenesis; plasticity; sox9; yap activation ... See more keywords
YAP regulates liver size and function
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1407390
Abstract: The liver is one of the main detoxifying organs, removing waste and xenobiotics through metabolic conversion and biliary excretion. The waste and xenobiotics come from the gastrointestinal tract via the portal vein, and diffuse into… read more here.
Keywords: yap activation; yap; hippo pathway; active yap ... See more keywords