Downregulation of YAP Activity Restricts P53 Hyperactivation to Promote Cell Survival in Confinement.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202302228
Abstract: Cell migration through confining three dimensional (3D) topographies can lead to loss of nuclear envelope integrity, DNA damage, and genomic instability. Despite these detrimental phenomena, cells transiently exposed to confinement do not usually die. Whether… read more here.
Keywords: nuclear envelope; cell; yap activity; confinement ... See more keywords
Abstract 325: The Regulation of Endothelial Function Through Hmgcr/mevalonate Pathway Mediated Yap Activity
Sign Up to like & getrecommendations! Published in 2020 at "Circulation Research"
DOI: 10.1161/res.127.suppl_1.325
Abstract: Background: Cardiovascular diseases (CVD) are the leading cause of death in the United States. Statins, a class of hydroxy-methylglutaryl-coenzyme A reductase (HMGCR) inhibitors, have been proven to be effectively prevent and treat CVD by improving… read more here.
Keywords: yap activity; analysis; hipsc ecs; hmgcr ... See more keywords
Baicalin Attenuates YAP Activity to Suppress Ovarian Cancer Stemness
Sign Up to like & getrecommendations! Published in 2020 at "OncoTargets and therapy"
DOI: 10.2147/ott.s254607
Abstract: Purpose This study aims to reveal the mechanism underlying baicalin-suppressing ovarian cancer stemness. Methods OVCAR-3 and the primary ovarian cancer cells were used for cell model. The ovarian cancer stem cells were isolated by suspension… read more here.
Keywords: ovarian cancer; stemness; cancer cells; cancer ... See more keywords
Assays Used for Discovering Small Molecule Inhibitors of YAP Activity in Cancers
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DOI: 10.3390/cancers14041029
Abstract: Simple Summary Cancer is a disease in which cells grow in an uncontrolled manner. This can be due to excessive cell proliferation or reduced cell death or a combination of the two. The Hippo signaling… read more here.
Keywords: small molecule; cell; yap activity; activity ... See more keywords