Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
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DOI: 10.1038/s41467-018-07338-z
Abstract: Activation of the Hippo pathway effector Yap underlies many liver cancers, however no germline or somatic mutations have been identified. Autophagy maintains essential metabolic functions of the liver, and autophagy-deficient murine models develop benign adenomas… read more here.
Keywords: degradation; autophagy gatekeeper; yap autophagy; liver ... See more keywords