Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis.
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DOI: 10.1016/j.canlet.2016.10.020
Abstract: Malignant mesothelioma (MM) frequently exhibits Hippo signaling pathway inactivation (HPI) mainly due to NF2 and/or LATS2 mutations, which leads to the activation of YAP transcriptional co-activator. Here, we show antitumor effects of statin on MM… read more here.
Keywords: yap cd44; cd44; hippo pathway; malignant mesothelioma ... See more keywords