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   Articles with "yap dependent" as a keyword



YAP drives cell competition by activating choline metabolism.

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recommendations! Published in 2021 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2021.07.101

Abstract: Cell competition is a phenomenon that eliminates unfit cells from cell society, a function vital for maintaining cellular and organismal homeostasis. We previously showed that Madin-Darby canine kidney (MDCK) epithelial cells expressing the active form… read more here.

Keywords: yap dependent; cell competition; competition; choline metabolism ... See more keywords

Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-51117-y

Abstract: Metabolic rewiring during the proliferation-to-quiescence transition is poorly understood. Here, using a model of contact inhibition-induced quiescence, we conducted 13C-metabolic flux analysis in proliferating (P) and quiescent (Q) mouse embryonic fibroblasts (MEFs) to investigate this… read more here.

Keywords: inhibition induced; inhibition; contact inhibition; quiescence ... See more keywords
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YAP-dependent proliferation by a small molecule targeting annexin A2

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recommendations! Published in 2021 at "Nature Chemical Biology"

DOI: 10.1038/s41589-021-00755-0

Abstract: The transcriptional coactivator Yes-associated protein 1 (YAP) orchestrates a proproliferative transcriptional program that controls the fate of somatic stem cells and the regenerative responses of certain tissues. As such, agents that activate YAP may hold therapeutic… read more here.

Keywords: dependent proliferation; yap dependent; small molecule; annexin ... See more keywords

Decoding YAP dependent transcription in the liver

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recommendations! Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac624

Abstract: Abstract The transcriptional coactivator YAP is emerging as a master regulator of cell growth. In the liver, YAP activity is linked to hepatomegaly, regeneration, dedifferentiation, and aggressive tumor growth. Here we present genomic studies to… read more here.

Keywords: decoding yap; transcription; yap dependent; transcription liver ... See more keywords