YAP drives cell competition by activating choline metabolism.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.07.101
Abstract: Cell competition is a phenomenon that eliminates unfit cells from cell society, a function vital for maintaining cellular and organismal homeostasis. We previously showed that Madin-Darby canine kidney (MDCK) epithelial cells expressing the active form… read more here.
Keywords: yap dependent; cell competition; competition; choline metabolism ... See more keywords
YAP-dependent proliferation by a small molecule targeting annexin A2
Sign Up to like & getrecommendations! Published in 2021 at "Nature Chemical Biology"
DOI: 10.1038/s41589-021-00755-0
Abstract: The transcriptional coactivator Yes-associated protein 1 (YAP) orchestrates a proproliferative transcriptional program that controls the fate of somatic stem cells and the regenerative responses of certain tissues. As such, agents that activate YAP may hold therapeutic… read more here.
Keywords: dependent proliferation; yap dependent; small molecule; annexin ... See more keywords
Decoding YAP dependent transcription in the liver
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac624
Abstract: Abstract The transcriptional coactivator YAP is emerging as a master regulator of cell growth. In the liver, YAP activity is linked to hepatomegaly, regeneration, dedifferentiation, and aggressive tumor growth. Here we present genomic studies to… read more here.
Keywords: decoding yap; transcription; yap dependent; transcription liver ... See more keywords