The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration
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DOI: 10.1038/s41569-018-0063-3
Abstract: The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and functionally conserved regulator of organ size and growth with crucial roles in cell proliferation, apoptosis, and differentiation. This pathway has great potential for therapeutic manipulation in… read more here.
Keywords: yap pathway; hippo; heart; regeneration ... See more keywords
(Pro)renin receptor involves in myocardial fibrosis and oxidative stress in diabetic cardiomyopathy via the PRR–YAP pathway
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-82776-2
Abstract: (Pro)renin receptor (PRR) and Yes-associated protein (YAP) play an important role in cardiovascular diseases. However, the role of PRR–YAP pathway in the pathogenesis of DCM is also not clear. We hypothesized that PRR–YAP pathway may… read more here.
Keywords: yap pathway; prr yap; myocardial fibrosis; prr ... See more keywords
Abstract 6991: Transcriptomic profiling of human and mouse models highlights YAP pathway hyperactivation as the underlying mechanism of the biological and clinical aggressiveness of Numb-defective bladder cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-6991
Abstract: In this study, we identify a previously uncharacterized role for the tumor suppressor, Numb, in bladder tumorigenesis, defining new predictive biomarkers and potentially actionable targets for the treatment of non-muscle-invasive bladder cancers. We conducted a… read more here.
Keywords: cancer; bladder cancer; bladder; human mouse ... See more keywords
The Hippo-YAP pathway in various cardiovascular diseases: Focusing on the inflammatory response
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DOI: 10.3389/fimmu.2022.971416
Abstract: The Hippo pathway was initially discovered in Drosophila melanogaster and mammals as a key regulator of tissue growth both in physiological and pathological states. Numerous studies depict the vital role of the Hippo pathway in… read more here.
Keywords: hippo yap; yap pathway; cardiovascular diseases; immunology ... See more keywords
Clinical potential of the Hippo-YAP pathway in bladder cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.925278
Abstract: Bladder cancer (BC) is one of the world’s most frequent cancers. Surgery coupled with adjuvant platinum-based chemotherapy is the current standard of therapy for BC. However, a high proportion of patients progressed to chemotherapy-resistant or… read more here.
Keywords: yap pathway; bladder cancer; hippo yap; cancer ... See more keywords