Effect of titanium ions on the Hippo/YAP signaling pathway in regulating biological behaviors of MC3T3‐E1 osteoblasts
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.3590
Abstract: Titanium (Ti) and its corresponding alloys have been widely applied in dental and orthopedic implants. Owing to abrasion and corrosion of implants in the unfavorable electrolytic aqueous environment of the host body, Ti ions could… read more here.
Keywords: effect; signaling pathway; titanium; yap ... See more keywords
Functional significance of Hippo/YAP signaling for drug resistance in colorectal cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22883
Abstract: Colorectal cancer is a leading cause of cancer‐related death worldwide. While early stage colorectal cancer can be removed by surgery, patients with advanced disease are treated by chemotherapy, with 5‐Fluorouracil (5‐FU) as a main ingredient.… read more here.
Keywords: cancer; yap signaling; drug resistance; colorectal cancer ... See more keywords
Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Phytotherapy Research"
DOI: 10.1002/ptr.6184
Abstract: Targeted therapy has a pivotal role for the treatment of liver cancer. The aim of this current study was to examine the effects of decursin on the growth of HepG2 cells and the underlying mechanisms.… read more here.
Keywords: decursin; growth hepg2; growth; yap signaling ... See more keywords
Recent Advances of the Hippo/YAP Signaling Pathway in Brain Development and Glioma
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00762-9
Abstract: The Hippo signaling pathway is highly conserved from Drosophila melanogaster to mammals and plays a crucial role in organ size control, tissue regeneration, and tumor suppression. The Yes-associated protein (YAP) is an important transcriptional co-activator… read more here.
Keywords: signaling pathway; yap signaling; glioma; hippo yap ... See more keywords
Targeted Intervention of NF2-YAP Signaling Axis in CD24-Overexpressing Cells Contributes to Encouraging Therapeutic Effects in TNBC.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c10921
Abstract: Triple-negative breast cancer (TNBC) cells have not been usefully classified, and no targeted therapeutic plans are currently available, resulting in a high recurrence rate and metastasis potential. In this research, CD24high cells accounted for the… read more here.
Keywords: nf2 yap; cd24high cells; yap signaling; signaling axis ... See more keywords
Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis
Sign Up to like & getrecommendations! Published in 2022 at "Channels"
DOI: 10.1080/19336950.2022.2099381
Abstract: ABSTRACT Ovarian cancer (OC) is a highly malignant cancer with great metastatic potential. Here we aimed to investigate the role of Piezo1, a gene related to the mechanical environment of the tumor, in promoting the… read more here.
Keywords: metastasis; ovarian cancer; yap signaling; hippo yap ... See more keywords
Hippo-YAP signaling activation and cross talk with PI3K in oral cancer: A retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2022 at "Oral diseases"
DOI: 10.1111/odi.14350
Abstract: OBJECTIVES This study aimed to investigate the clinical and prognostic relevance of the Hippo-YAP transactivators YAP1 and TAZ in oral squamous cell carcinoma, and their possible relationship with PI3K/mTOR pathway activation. MATERIALS AND METHODS Immunohistochemical… read more here.
Keywords: nuclear yap1; activation; expression; yap signaling ... See more keywords
Oncogenic Activation of YAP Signaling Sensitizes Ferroptosis of Hepatocellular Carcinoma via ALOXE3-Mediated Lipid Peroxidation Accumulation
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.751593
Abstract: Ferroptosis, a form of programmed cell death process driven by iron-dependent lipid peroxidation, plays an important role in tumor suppression. Although previous study showed that intracellular Merlin-Hippo signaling suppresses ferroptosis of epithelial tumor cells through… read more here.
Keywords: ferroptosis; yap; activation yap; hcc ... See more keywords
HIF-1α/YAP Signaling Rewrites Glucose/Iodine Metabolism Program to Promote Papillary Thyroid Cancer Progression
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.75459
Abstract: Background: The management of aggressive and progressive metastatic papillary thyroid cancer (PTC) is very difficult. An inverse relationship between radioiodine and F-18 fluorodeoxyglucose (FDG) uptake (''flip-flop'' phenomenon) is described for invasive PTC during dedifferentiation. However,… read more here.
Keywords: ptc; glucose iodine; yap; yap signaling ... See more keywords
CXCR4 mediates matrix stiffness-induced downregulation of UBTD1 driving hepatocellular carcinoma progression via YAP signaling pathway
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DOI: 10.7150/thno.44789
Abstract: Rational: Increasing evidence indicates that the physical environment is a critical mediator of tumor behavior. Hepatocellular carcinoma (HCC) develops in an altered biomechanical environment, and increased matrix stiffness is a strong predictor of HCC development.… read more here.
Keywords: matrix stiffness; hcc; stiffness; signaling pathway ... See more keywords