Molecular Features of the YAP Inhibitor Verteporfin: Synthesis of Hexasubstituted Dipyrrins as Potential Inhibitors of YAP/TAZ, the Downstream Effectors of the Hippo Pathway
Sign Up to like & getrecommendations! Published in 2017 at "ChemMedChem"
DOI: 10.1002/cmdc.201700063
Abstract: Porphyrin derivatives, in particular verteporfin (VP), a photosensitizer initially designed for cancer therapy, have been identified as inhibitors of the YAP–TEAD interaction and transcriptional activity. Herein we report the efficient convergent synthesis of the dipyrrin… read more here.
Keywords: inhibitors yap; vinyl; verteporfin; yap taz ... See more keywords
The role of Hippo‐YAP/TAZ signaling in brain development
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Dynamics"
DOI: 10.1002/dvdy.504
Abstract: In order for our complex nervous system to develop normally, both precise spatial and temporal regulation of a number of different signaling pathways is critical. During both early embryogenesis and in organ development, one pathway… read more here.
Keywords: taz signaling; role; brain development; development ... See more keywords
Piezo channels contribute to the regulation of myelination in Schwann cells
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DOI: 10.1002/glia.24251
Abstract: Peripheral nerves and Schwann cells have to sustain constant mechanical constraints, caused by developmental growth as well as stretches associated with movements of the limbs and mechanical compressions from daily activities. In Schwann cells, signaling… read more here.
Keywords: schwann cells; yap taz; schwann; regulation ... See more keywords
SDHA/B reduction promotes hepatocellular carcinoma by facilitating the deNEDDylation of cullin1 and stabilizing YAP/TAZ.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32621
Abstract: BACKGROUND & AIMS Succinate dehydrogenase enzyme (SDH) is frequently diminished in Hepatocellular carcinoma (HCC) patient samples, and SDH reduction is associated with elevated succinate level and poor prognosis in HCC patients. But the underlying mechanisms… read more here.
Keywords: hcc; sdha reduction; taz; yap taz ... See more keywords
Differential requirement of Hippo cascade during CTNNB1 or AXIN1 mutation‐driven hepatocarcinogenesis
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DOI: 10.1002/hep.32693
Abstract: Background and Aims: Gain‐of‐function (GOF) mutations of CTNNB1 and loss‐of‐function (LOF) mutations of AXIN1 are recurrent genetic alterations in hepatocellular carcinoma (HCC). We aim to investigate the functional contribution of Hippo/YAP/TAZ in GOF CTNNB1 or… read more here.
Keywords: hcc; yap taz; met sgaxin1; yap ... See more keywords
Cancer mechanobiology: Effects and therapeutic perspectives
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DOI: 10.1002/ijc.31221
Abstract: A growing body of evidence provides new insights regarding the effect of aberrant mechanosensing of the extracellular matrix (ECM) and corresponding devious mechanotransduction of cancer cells and their surrounding stromal cells in tumorigenesis. Among others,… read more here.
Keywords: yap taz; microscopy; dna; activation ... See more keywords
Regulation of YAP/TAZ Activity by Mechanical Cues: An Experimental Overview.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8910-2_15
Abstract: YAP/TAZ activity is regulated by a complex network of signals that include the Hippo pathway, cell polarity complexes, and signaling receptors of the RTK, GPCR, and WNT pathways and by a seamlessly expanding number of… read more here.
Keywords: yap taz; taz activity; mechanical cues; regulation yap ... See more keywords
Determining the Phosphorylation Status of Hippo Components YAP and TAZ Using Phos-tag.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8910-2_21
Abstract: Protein phosphorylation is one of the most important posttranslational modifications in cell signaling and regulation. Protein phosphorylation can be detected by site-specific phospho-antibodies, but generating these antibodies can be costly, time-consuming, and difficult. Recently, Phos-tag… read more here.
Keywords: phosphorylation status; phos tag; yap taz; phosphorylation ... See more keywords
Expression pattern of YAP and TAZ during orthodontic tooth movement in rats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Histology"
DOI: 10.1007/s10735-017-9752-1
Abstract: Orthodontic tooth movement (OTM) is a periodontal tissue remodeling and regeneration process that is caused by bio-mechanical stimulation. This mechanical–chemical transduction process involves a variety of biological factors and signaling pathways. It has been shown… read more here.
Keywords: yap taz; tooth movement; expression; orthodontic tooth ... See more keywords
YAP/TAZ affects the development of pulmonary fibrosis by regulating multiple signaling pathways
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DOI: 10.1007/s11010-020-03866-9
Abstract: YAP and TAZ are important co-activators of various biological processes in human body. YAP/TAZ plays a vital role in the development of pulmonary fibrosis. Dysregulation of the YAP/TAZ signaling pathway is one of the most… read more here.
Keywords: yap taz; development pulmonary; pulmonary fibrosis;
Fibulin-5 promotes airway smooth muscle cell proliferation and migration via modulating Hippo-YAP/TAZ pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.09.105
Abstract: Asthma is a common chronic disease mainly occurs from childhood. Increased airway smooth muscle mass is involved in the pathogenesis of asthma. Fibulin-5 was upregulated in the lung tissues of patients with COPD and idiopathic… read more here.
Keywords: yap taz; fibulin; proliferation migration;