Deubiquitinating enzyme USP10 promotes osteosarcoma metastasis and epithelial-mesenchymal transition by stabilizing YAP1.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6074
Abstract: BACKGROUND Osteosarcoma (OS) is a fatal adolescent tumor, which is susceptible to remote metastases at an early stage, and its treatment remains a major challenge. ubiquitin-specific protease 10 (USP10) is primarily located in the cytoplasm… read more here.
Keywords: metastasis; mesenchymal transition; metastasis epithelial; epithelial mesenchymal ... See more keywords
Involvement of Yes‐associated protein 1 (YAP1) in doxorubicin‐induced cytotoxicity in H9c2 cardiac cells
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11285
Abstract: Cardiac cell death is one of the major events implicated in doxorubicin‐induced cardiotoxicity, which leads to heart failure. We recently reported that Yes‐associated protein 1 (YAP1) regulates cell survival and apoptosis. However, it is unclear… read more here.
Keywords: protein; yap1; doxorubicin induced; cell death ... See more keywords
Multi-omics characterization of mouse hepatoblastoma identifies novel YAP1 target genes.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32713
Abstract: BACKGROUND & AIMS Hepatoblastoma (HB) is the most common primary liver malignancy in childhood, and lacks targeted therapeutic options. We previously engineered the first Yes Associated Protein 1 (YAP1S127A )-inducible mouse model of HB, demonstrating… read more here.
Keywords: novel yap1; multi omics; mouse; yap1 ... See more keywords
MZF1 and GABP Cooperate with Sox2 in Regulating the Expression of YAP1 in Cancer Cells
Sign Up to like & getrecommendations! Published in 2017 at "Stem Cells"
DOI: 10.1002/stem.2705
Abstract: The transcription factor YAP1 is a major effector of the tumor suppressive Hippo signaling pathway and is also necessary to maintain pluripotency in embryonic stem cells. Elevated levels of YAP1 expression antagonize the tumor suppressive… read more here.
Keywords: yap1; yap1 expression; expression; sox2 ... See more keywords
An innovative targeted therapy for fluoroscopy-induced chronic radiation dermatitis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular medicine"
DOI: 10.1007/s00109-021-02146-3
Abstract: Fluoroscopy-induced chronic radiation dermatitis (FICRD) is a complication of fluoroscopy-guided intervention. Unlike acute radiation dermatitis, FICRD is different as delayed onset and usually appears without preexisting acute dermatitis. Unfortunately, the chronic and progressive pathology of… read more here.
Keywords: yap1; radiation dermatitis; therapy; dermatitis ... See more keywords
Cisplatin promotes the expression level of PD-L1 in the microenvironment of hepatocellular carcinoma through YAP1
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-020-03861-0
Abstract: Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. However, the immune tolerance limits the effect of chemotherapeutic drugs. Therefore, the mechanism of cisplatin in promoting PD-L1 expression by YAP1 was investigated in… read more here.
Keywords: cisplatin; microenvironment; yap1; expression level ... See more keywords
C11orf95-RELA fusions and upregulated NF-KB signalling characterise a subset of aggressive supratentorial ependymomas that express L1CAM and nestin
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2767-y
Abstract: Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines… read more here.
Keywords: rela; yap1; l1cam; c11orf95 rela ... See more keywords
CGRP-modulated M2 macrophages regulate osteogenesis of MC3T3-E1 via Yap1.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108697
Abstract: Bone fractures are one of the most frequent injuries in the musculoskeletal system. Despite the best treatment efforts, a large proportion of bone fracture cases still display undesirable outcomes. Here, we verified that calcitonin gene-related… read more here.
Keywords: yap1; cgrp modulated; cgrp; regulate osteogenesis ... See more keywords
YAP1 induces marrow derived suppressor cell recruitment in Chlamydia trachomatis infection.
Sign Up to like & getrecommendations! Published in 2021 at "Immunology letters"
DOI: 10.1016/j.imlet.2021.12.003
Abstract: Chlamydia trachomatis (C. trachomatis) is the most commonly diagnosed bacterial sexually transmitted infection (STI) worldwide. Marrow derived suppressor cells (MDSCs) are a heterogeneous population of immature monocytes and granulocytes, which are effective inhibitors for T… read more here.
Keywords: marrow derived; chlamydia trachomatis; infection; trachomatis ... See more keywords
The novel axis of YAP1, transcription enhancer factor 3 and Down Syndrome Candidate Region 1 isoform 1L is a common signaling pathway downstream of several angiogenic factors.
Sign Up to like & getrecommendations! Published in 2019 at "Microvascular research"
DOI: 10.1016/j.mvr.2019.103955
Abstract: Angiogenesis is a hallmark of many diseases. Previously, we found that Down Syndrome Candidate Region 1 Isoform 1L (DSCR1-1L) was expressed in human tumor vessels, but was not detectable in normal tissues, and played important… read more here.
Keywords: yap1; growth; syndrome candidate; dscr1 ... See more keywords
Hippo-YAP1 signaling pathway and severe preeclampsia (sPE) in the Chinese population.
Sign Up to like & getrecommendations! Published in 2019 at "Pregnancy hypertension"
DOI: 10.1016/j.preghy.2019.11.002
Abstract: BACKGROUND The present study aims to explore the possible mechanisms of Hippo-YAP1 signaling pathway in the development of severe preeclampsia (sPE). METHODS A total of 14 pregnancies complicated with severe preeclampsia as well as 14… read more here.
Keywords: yap1; hippo yap1; mst; group ... See more keywords