VGLL4 inhibits YAP1/TEAD signaling to suppress the epidermal squamous cell carcinoma cancer phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23307
Abstract: Epidermal squamous cell carcinoma (SCC) develops in response to ultraviolet light exposure and is among the most common cancers. The transglutaminase 2 cancer cell survival protein stimulates the activity of the YAP1/TEAD transcription complex to… read more here.
Keywords: yap1 tead; cancer phenotype; expression; cancer ... See more keywords
NOTCH-YAP1/TEAD-DNMT1 axis drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.05.007
Abstract: BACKGROUND AND AIM Intrahepatic cholangiocarcinoma (ICC) is a devastating liver cancer with extremely high intra- and inter-tumoral molecular heterogeneity, partly due to its diverse cellular origins. We investigated clinical relevance and the molecular mechanisms underlying… read more here.
Keywords: yap1 tead; dnmt1; yap1; icc development ... See more keywords
Abstract 7377: Deep learning uncovers morphological patterns of YAP1/TEAD activity related to disease aggressiveness in cancer patients
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-7377
Abstract: Hippo signaling emerged over the last decade as a major tumor-suppressing pathway. Its dysregulation is generally associated with abnormal expression levels of YAP1, WWTR1 (coding for the TAZ protein) and TEAD genes among others. This… read more here.
Keywords: deep learning; cancer; disease aggressiveness; tead activity ... See more keywords