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   Articles with "ybx1" as a keyword



ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202507254

Abstract: The overexpression of ALKBH5 alleviates damage to cardiomyocytes and tissues, decreases the expression of SLC7A11, and inhibits the expression of p53N/T and ferroptosis. ALKBH5 induces ferroptosis in the HH/R model by mutating the 3′‐UTR of… read more here.

Keywords: alkbh5; 142 173; p53; g3bp1 ... See more keywords

Transcriptional activation of NANOG by YBX1 promotes lung cancer stem-like properties and metastasis.

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recommendations! Published in 2017 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.04.033

Abstract: Aberrant overexpression of the transcription/translation factor Y-box-binding protein-1 (YBX1) is associated with non-small cell lung cancer (NSCLC) aggressiveness. Cancer stem cells (CSCs) contribute to the tumorigenesis and metastasis of NSCLC. Hitherto, the mechanism by which… read more here.

Keywords: cancer stem; ybx1; lung cancer; cancer ... See more keywords

Dysregulated Expression of the MicroRNA miR‐137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma

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recommendations! Published in 2018 at "Journal of Thoracic Oncology"

DOI: 10.1016/j.jtho.2017.10.016

Abstract: Introduction: Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure. On a genomic level, MPM is characterized by frequent chromosomal deletions of tumor suppressors, including microRNAs. MiR‐137 plays a tumor suppressor role… read more here.

Keywords: mir 137; mpm; ybx1; target ... See more keywords

YBX1 Modulates 8-Oxoguanine Recognition and Repair in DNA.

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recommendations! Published in 2025 at "ACS chemical biology"

DOI: 10.1021/acschembio.4c00831

Abstract: 8-Oxoguanine (8-oxoG) is not only a biomarker of oxidative DNA damage but also an epigenetic-like regulator in mammalian cells. The identification and characterization of 8-oxoG-binding proteins would be crucial for further understanding the biological consequences… read more here.

Keywords: modulates oxoguanine; oxoguanine recognition; ybx1 modulates; repair ... See more keywords

SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis

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recommendations! Published in 2025 at "Oncogene"

DOI: 10.1038/s41388-025-03302-6

Abstract: Aberrant SUMOylation is associated with the progression of colorectal cancer (CRC). The SUMO-specific protease 1 (SENP1)-induced deSUMOylation of different target substrates plays specific roles in CRC. In this study, we dissected the SENP1-interacting protein complex… read more here.

Keywords: senp1 mediated; senp1 ybx1; desumoylation; protein ... See more keywords

Broad role for YBX1 in defining the small noncoding RNA composition of exosomes

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recommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1712108114

Abstract: Significance Cells release vesicles containing selectively packaged cargo, including RNA, into the extracellular environment. Prior studies have identified RNA inside extracellular vesicles (EVs), but due to limitations of conventional sequencing methods, highly structured and posttranscriptionally… read more here.

Keywords: ybx1; small noncoding; rna; role ... See more keywords

Translational co-regulation of a ligand and inhibitor by a conserved RNA element

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recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkx938

Abstract: Abstract In many organisms, transcriptional and post-transcriptional regulation of components of pathways or processes has been reported. However, to date, there are few reports of translational co-regulation of multiple components of a developmental signaling pathway.… read more here.

Keywords: rna element; ybx1; ligand; translational regulation ... See more keywords

YBX1 is required for assembly of viral replication complexes of chikungunya virus and replication of multiple alphaviruses

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recommendations! Published in 2024 at "Journal of Virology"

DOI: 10.1128/jvi.02015-24

Abstract: ABSTRACT Chikungunya virus (CHIKV), an enveloped positive-sense RNA virus, is a member of the alphaviruses and cause fever and arthralgia in humans. We performed genome-wide CRISPR/Cas9-based screens and identified Y-box binding protein 1 (YBX1) as… read more here.

Keywords: replication; chikv; rna; multiple alphaviruses ... See more keywords

Abstract LB209: YBX1 is a negative regulator of post-transcriptional program associated to EMT, invasion and metastasis in cSCC

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/1538-7445.am2024-lb209

Abstract: Y-box binding protein 1 (YB-1), which is encoded by YBX1 gene, is a multifunctional cold-shock protein that binds both DNA and RNA to orchestrate transcription as well as RNA processing and translation. Recently, we demonstrated… read more here.

Keywords: cscc; post transcriptional; cell; invasion ... See more keywords

YBX1 promotes type H vessel–dependent bone formation in an m5C-dependent manner

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recommendations! Published in 2024 at "JCI Insight"

DOI: 10.1172/jci.insight.172345

Abstract: RNA-binding proteins (RBPs) interact with RNA and ubiquitously regulate RNA transcripts during their life cycle, playing a fundamental role in the progression of angiogenesis-related diseases. In the skeletal system, endothelium-dependent angiogenesis is indispensable for bone… read more here.

Keywords: dependent bone; m5c dependent; bone formation; bone ... See more keywords

CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1

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recommendations! Published in 2022 at "Journal of Translational Medicine"

DOI: 10.1186/s12967-021-03206-5

Abstract: Background Cytidine nucleotide triphosphate synthase 1 (CTPS1) is a CTP synthase which play critical roles in DNA synthesis. However, its biological regulation and mechanism in triple-negative breast cancer (TNBC) has not been reported yet. Methods… read more here.

Keywords: ybx1; triple negative; ctps1; tnbc ... See more keywords