Transcriptional activation of NANOG by YBX1 promotes lung cancer stem-like properties and metastasis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.04.033
Abstract: Aberrant overexpression of the transcription/translation factor Y-box-binding protein-1 (YBX1) is associated with non-small cell lung cancer (NSCLC) aggressiveness. Cancer stem cells (CSCs) contribute to the tumorigenesis and metastasis of NSCLC. Hitherto, the mechanism by which… read more here.
Keywords: cancer stem; ybx1; lung cancer; cancer ... See more keywords
Dysregulated Expression of the MicroRNA miR‐137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2017.10.016
Abstract: Introduction: Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure. On a genomic level, MPM is characterized by frequent chromosomal deletions of tumor suppressors, including microRNAs. MiR‐137 plays a tumor suppressor role… read more here.
Keywords: mir 137; mpm; ybx1; target ... See more keywords
Broad role for YBX1 in defining the small noncoding RNA composition of exosomes
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1712108114
Abstract: Significance Cells release vesicles containing selectively packaged cargo, including RNA, into the extracellular environment. Prior studies have identified RNA inside extracellular vesicles (EVs), but due to limitations of conventional sequencing methods, highly structured and posttranscriptionally… read more here.
Keywords: ybx1; small noncoding; rna; role ... See more keywords
Translational co-regulation of a ligand and inhibitor by a conserved RNA element
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx938
Abstract: Abstract In many organisms, transcriptional and post-transcriptional regulation of components of pathways or processes has been reported. However, to date, there are few reports of translational co-regulation of multiple components of a developmental signaling pathway.… read more here.
Keywords: rna element; ybx1; ligand; translational regulation ... See more keywords
CTPS1 promotes malignant progression of triple-negative breast cancer with transcriptional activation by YBX1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-021-03206-5
Abstract: Background Cytidine nucleotide triphosphate synthase 1 (CTPS1) is a CTP synthase which play critical roles in DNA synthesis. However, its biological regulation and mechanism in triple-negative breast cancer (TNBC) has not been reported yet. Methods… read more here.
Keywords: ybx1; triple negative; ctps1; tnbc ... See more keywords
Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.26469
Abstract: The enhanced expression of the Y-box binding protein YBX1 is consistently correlated with poor outcomes or reduced survival of breast cancer patients. However, the mechanism underlying the association between increased YBX1 expression and poor outcomes… read more here.
Keywords: poor outcomes; ybx1; correlated genes; breast cancer ... See more keywords
AB094. C1QBP negatively regulates the activation of oncoprotein YBX1 in the renal cell carcinoma as revealed by interactomics analysis
Sign Up to like & getrecommendations! Published in 2017 at "Translational Andrology and Urology"
DOI: 10.21037/tau.2017.s094
Abstract: Background The Y-box-binding protein 1 (YBX1) plays a critical role in tumorigenesis by promoting cell proliferation, overriding cell cycle check points, and enhancing genomic instability. Methods The interactome of YBX1 in renal cell carcinoma (RCC)… read more here.
Keywords: renal cell; ybx1 renal; carcinoma; ybx1 ... See more keywords
YBX1 promotes tumor progression via the PI3K/AKT signaling pathway in laryngeal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Translational Cancer Research"
DOI: 10.21037/tcr-21-2087
Abstract: Background Laryngeal squamous cell carcinoma (LSCC) is one of the most commonly seen malignancies of the head and neck, with increasing incidence and mortality. The Y-box-binding protein 1 (YBX1) is a type of oncoprotein which… read more here.
Keywords: ybx1; squamous cell; laryngeal squamous; cell ... See more keywords
Drosophila YBX1 homolog YPS promotes ovarian germline stem cell development by preferentially recognizing 5-methylcytosine RNAs
Sign Up to like & getrecommendations! Published in 2020 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.2210/pdb6ktc/pdb
Abstract: 5-Methylcytosine (m5C) is a RNA modification that exists in tRNAs and rRNAs and was recently found in mRNAs. Although it has been suggested to regulate diverse biological functions, whether m5C RNA modification influences adult stem… read more here.
Keywords: development; stem cell; ybx1; cell development ... See more keywords