The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity
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DOI: 10.15252/emmm.202113952
Abstract: Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD). However, the etiology of its noxious cellular effects remains elusive. In a combinatory genetic and proteomic approach using a yeast model… read more here.
Keywords: amyloid beta; hsp40 chaperone; toxicity; ydj1 ... See more keywords
Optimization of a Methodology for Quantification and Removal of Zinc Gives Insights Into the Effect of This Metal on the Stability and Function of the Zinc-Binding Co-chaperone Ydj1
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2019.00416
Abstract: Ydj1, a class B J-protein (Hsp40) in yeast, has two zinc finger domains in each monomer and belongs to an important co-chaperone family that plays crucial roles in cells, such as recognizing and binding partially… read more here.
Keywords: protein; methodology; zinc; effect ... See more keywords