A yeast‐based complementation assay elucidates the functional impact of 200 missense variants in human PSAT1
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Inherited Metabolic Disease"
DOI: 10.1002/jimd.12227
Abstract: Defects in serine biosynthesis resulting from loss of function mutations in PHGDH, PSAT1, and PSPH cause a set of rare, autosomal recessive diseases known as Neu‐Laxova syndrome (NLS) or serine‐deficiency disorders. The diseases present with… read more here.
Keywords: yeast based; functional impact; assay; psat1 ... See more keywords
A yeast‐based tool for screening mammalian diacylglycerol acyltransferase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1334
Abstract: Dysregulation of lipid metabolism is associated with obesity and metabolic diseases but there is also increasing evidence of a relationship between lipid body excess and cancer. Lipid body synthesis requires diacylglycerol acyltransferases (DGATs) which catalyze… read more here.
Keywords: yeast based; diacylglycerol; based tool; screening mammalian ... See more keywords
Yeast-based assays for detecting protein-protein/drug interactions and their inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of cell biology"
DOI: 10.1016/j.ejcb.2017.06.003
Abstract: Understanding cellular processes at molecular levels in health and disease requires the knowledge of protein-protein interactions (PPIs). In line with this, identification of PPIs at genome-wide scale is highly valuable to understand how different cellular… read more here.
Keywords: assays detecting; based assays; protein protein; protein drug ... See more keywords
Yeast-Based Synthetic Biology Platform for Antimicrobial Peptide Production.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.7b00396
Abstract: Antibiotic resistance is one of the most challenging global health threats in our society. Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics for the treatment of drug-resistant infections. However, they are limited by their… read more here.
Keywords: based synthetic; production; synthetic biology; biology ... See more keywords
A yeast-based in vivo assay system for analyzing efflux of sugars mediated by glucose and xylose transporters.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS yeast research"
DOI: 10.1093/femsyr/foac038
Abstract: Sugar transporter research focuses on the sugar uptake into cells. Under certain physiological conditions, however, the intracellular accumulation and secretion of carbohydrates (efflux) are relevant processes in many cell types. Currently, no cell-based system is… read more here.
Keywords: based vivo; system; glucose efflux; yeast based ... See more keywords
Influence of yeast-based pre- and probiotics in lactation and nursery diets on nursery pig performance and antimicrobial resistance of fecal Escherichia coli.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of animal science"
DOI: 10.1093/jas/skac166
Abstract: Two experiments were conducted to determine the impact of various combinations of yeast-based direct fed microbials (DFM) in diets fed to nursery pigs weaned from sows fed lactation diets with or without yeast additives. In… read more here.
Keywords: yeast based; yeast additives; yeast; resistance ... See more keywords
Yeast-based evolutionary modeling of androgen receptor mutations and natural selection
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010518
Abstract: Cancer progression is associated with the evolutionary accumulation of genetic mutations that are biologically significant. Mutations of the androgen receptor (AR) are associated with the development of prostate cancer (PCa) by responding to non-androgenic hormones,… read more here.
Keywords: steroidal ligands; yeast based; androgen receptor; based evolutionary ... See more keywords
Comparison of antibiotic supplementation versus a yeast-based prebiotic on the cecal microbiome of commercial broilers
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0182805
Abstract: Prebiotics are defined as fermentable food ingredients that selectively stimulate beneficial bacteria in the lower gastrointestinal tract of the host. The purpose of this study was to assess growth performance of broilers and the cecal… read more here.
Keywords: supplementation versus; antibiotic supplementation; white meat; versus yeast ... See more keywords
A Yeast-Based Functional Assay to Study Plant N-Degron – N-Recognin Interactions
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.806129
Abstract: The N-degron pathway is a branch of the ubiquitin-proteasome system where amino-terminal residues serve as degradation signals. In a synthetic biology approach, we expressed ubiquitin ligase PRT6 and ubiquitin conjugating enzyme 2 (AtUBC2) from Arabidopsis… read more here.
Keywords: degron; yeast based; degron pathway; plant degron ... See more keywords
Yeast-Based Biosensors: Current Applications and New Developments
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DOI: 10.3390/bios10050051
Abstract: Biosensors are regarded as a powerful tool to detect and monitor environmental contaminants, toxins, and, more generally, organic or chemical markers of potential threats to human health. They are basically composed of a sensor part… read more here.
Keywords: applications new; current applications; yeast based; based biosensors ... See more keywords
Two flavonoid-based compounds from Murraya paniculata as novel human carbonic anhydrase isozyme II inhibitors detected by a resazurin yeast-based assay.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of microbiology and biotechnology"
DOI: 10.4014/jmb.1910.10037
Abstract: Human carbonic anhydrase isozyme II has been used as protein target for disorder treatment including glaucoma. Current clinically used sulfonamide-based CA inhibitors can induce side effects, and so alternatives are required. This study aimed to… read more here.
Keywords: carbonic anhydrase; human carbonic; murraya paniculata; yeast based ... See more keywords