Engineering the Active Site Lid Dynamics to Improve the Catalytic Efficiency of Yeast Cytosine Deaminase
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DOI: 10.3390/ijms24076592
Abstract: Conformational dynamics is important for enzyme catalysis. However, engineering dynamics to achieve a higher catalytic efficiency is still challenging. In this work, we develop a new strategy to improve the activity of yeast cytosine deaminase… read more here.
Keywords: catalytic efficiency; cytosine deaminase; site lid; active site ... See more keywords