Yeast and Human Nuclear Pore Complexes: Not So Similar After All.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2018.06.004
Abstract: Nucleoporin subunits that generate the nuclear pore complex (NPC) are highly conserved in evolution. High-resolution structures of the NPC are available, but the actual NPC composition in yeast has only been quantified recently. Two studies… read more here.
Keywords: complexes similar; pore complexes; human nuclear; nuclear pore ... See more keywords
Bedaquiline inhibits the yeast and human mitochondrial ATP synthases
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01173-z
Abstract: Bedaquiline (BDQ, Sirturo) has been approved to treat multidrug resistant forms of Mycobacterium tuberculosis. Prior studies suggested that BDQ was a selective inhibitor of the ATP synthase from M. tuberculosis. However, Sirturo treatment leads to… read more here.
Keywords: human mitochondrial; mitochondrial atp; bdq; atp synthases ... See more keywords
Identification of a small RhoA GTPase inhibitor effective in fission yeast and human cells
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DOI: 10.1098/rsob.220185
Abstract: The Rho GTPase family proteins are key regulators of cytoskeletal dynamics. Deregulated activity of Rho GTPases is associated with cancers and neurodegenerative diseases, and their potential as drug targets has long been recognized. Using an… read more here.
Keywords: yeast human; human cells; inhibitor; gtpase ... See more keywords
α-Arrestins and Their Functions: From Yeast to Human Health
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DOI: 10.3390/ijms23094988
Abstract: α-Arrestins, also called arrestin-related trafficking adaptors (ARTs), constitute a large family of proteins conserved from yeast to humans. Despite their evolutionary precedence over their extensively studied relatives of the β-arrestin family, α-arrestins have been discovered… read more here.
Keywords: health; yeast human; human health; arrestins functions ... See more keywords
Highly efficient 5' capping of mitochondrial RNA with NAD+ and NADH by yeast and human mitochondrial RNA polymerase
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.42179
Abstract: Bacterial and eukaryotic nuclear RNA polymerases (RNAPs) cap RNA with the oxidized and reduced forms of the metabolic effector nicotinamide adenine dinucleotide, NAD+ and NADH, using NAD+ and NADH as non-canonical initiating nucleotides for transcription… read more here.
Keywords: nad nadh; rna nad; human mitochondrial; rna ... See more keywords