Short disordered protein segment regulates cross-species transmission of a yeast prion
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DOI: 10.1038/s41589-020-0516-y
Abstract: Soluble prion proteins contingently encounter foreign prion aggregates, leading to cross-species prion transmission. However, how its efficiency is regulated by structural fluctuation of the host soluble prion protein remains unsolved. In the present study, through… read more here.
Keywords: cross species; short disordered; transmission; segment ... See more keywords
Amyloid conformation-dependent disaggregation in a reconstituted yeast prion system
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DOI: 10.1038/s41589-021-00951-y
Abstract: Disaggregation of amyloid fibrils is a fundamental biological process required for amyloid propagation. However, due to the lack of experimental systems, the molecular mechanism of how amyloid is disaggregated by cellular factors remains poorly understood.… read more here.
Keywords: conformation dependent; system; disaggregation; yeast prion ... See more keywords