Yes‐Associated Protein in Kupffer Cells Enhances the Production of Proinflammatory Cytokines and Promotes the Development of Nonalcoholic Steatohepatitis
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30990
Abstract: Yes‐associated protein (YAP) plays an important role in hepatocarcinogenesis, although the potential role of YAP in non‐neoplastic liver diseases remains largely unknown. We report herein that YAP in Kupffer cells (KCs) enhances the production of… read more here.
Keywords: associated protein; proinflammatory cytokines; kupffer cells; production proinflammatory ... See more keywords
Multivalent Angiomotin‐like 1 and Yes‐associated protein form a dynamic complex
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DOI: 10.1002/pro.4295
Abstract: Multivalent complexes formed between the cancer‐promoting transcriptional co‐activator, Yes‐associated protein (YAP), and proteins containing short linear motifs of type PPxY modulate cell proliferation and are attractive therapeutic targets. However, challenges producing PPxY polypeptides containing the… read more here.
Keywords: amotl1; yes associated; ppxy; angiomotin like ... See more keywords
Induction of apoptosis using ATN as a novel Yes‐associated protein inhibitor in human oral squamous cell carcinoma cells
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23493
Abstract: Oral squamous cell carcinoma (OSCC) represents a clinical challenge due to the lack of effective therapy to improve prognosis. Hippo/Yes‐associated protein (YAP) signaling has emerged as a promising therapeutic target for squamous cell carcinoma treatment.… read more here.
Keywords: cell carcinoma; cell; yes associated; squamous cell ... See more keywords
Periodontal ligament fibroblast-derived exosomes induced by compressive force promote macrophage M1 polarization via Yes-associated protein.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2021.105263
Abstract: OBJECTIVES This study aimed to investigate the biological roles and mechanisms of compressive force-stimulated periodontal ligament fibroblasts (PDLFs) on polarization of macrophages DESIGN: PDLFs were stimulated with or without static compressive force, and then conditioned… read more here.
Keywords: periodontal ligament; compressive force; polarization; force ... See more keywords
Yes-Associated Protein and PDZ Binding Motif: A Critical Signaling Pathway in the Control of Human Pluripotent Stem Cells Self-Renewal and Differentiation.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular reprogramming"
DOI: 10.1089/cell.2019.0084
Abstract: Human pluripotent stem cells (hPSCs) can self-renew indefinitely to generate cells like themselves with a normal karyotype and differentiate into other types of cells when stimulated with a proper set of internal and external signals.… read more here.
Keywords: associated protein; human pluripotent; pluripotent stem; stem ... See more keywords
Prognostic significance of nuclear Yes-associated protein 1 in patients with nonsmall cell lung cancer
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DOI: 10.1097/md.0000000000015069
Abstract: Background: Nuclear Yes-associated protein 1 (YAP1) has often been regarded as an adverse prognostic indicator in various tumors. Recent studies have associated YAP1 with unfavorable prognosis in nonsmall cell lung cancer (NSCLC). However, due to… read more here.
Keywords: expression; nuclear yap1; yes associated; cancer ... See more keywords
The role of Hippo/yes‐associated protein signalling in vascular remodelling associated with cardiovascular disease
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DOI: 10.1111/bph.13806
Abstract: Vascular remodelling is a vital process of a wide range of cardiovascular diseases and represents the altered structure and arrangement of blood vessels. The Hippo pathway controls organ size by regulating cell survival, proliferation and… read more here.
Keywords: vascular remodelling; associated protein; yes associated; signalling vascular ... See more keywords
The cytoprotective impact of yes-associated protein 1 after ischemia-reperfusion injury in AC16 human cardiomyocytes
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Biology and Medicine"
DOI: 10.1177/1535370219851243
Abstract: The Hippo-signaling pathway is a mechanism implicated in cardiomyocyte cytoprotection and regeneration after a myocardial infarction. Yes-associated protein 1, the main effector protein of this pathway, acts as a co-transcriptional activator to promote cardiomyocyte proliferation… read more here.
Keywords: associated protein; ischemia reperfusion; yes associated; reperfusion injury ... See more keywords
YAP activation in melanoma contributes to anoikis resistance and metastasis
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DOI: 10.1177/1535370220977101
Abstract: Melanoma is inherently heterogeneous, providing resistance to apoptosis. Anoikis resistance is a hallmark feature of metastatic melanoma to escape apoptosis when cells lose contact with adjacent cells or extracellular matrix. The yes-associated protein transcription co-activator… read more here.
Keywords: associated protein; melanoma; anoikis resistance; yes associated ... See more keywords
Yes-associated protein promotes endothelial-to-mesenchymal transition of endothelial cells in choroidal neovascularization fibrosis.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2022.05.03
Abstract: AIM To reveal whether and how Yes-associated protein (YAP) promotes the occurrence of subretinal fibrosis in age-related macular degeneration (AMD). METHODS Cobalt chloride (CoCl2) was used in primary human umbilical vein endothelial cells (HUVECs) to… read more here.
Keywords: endothelial cells; yes associated; associated protein; expression ... See more keywords
Yes-associated protein gene overexpression regulated by β-catenin promotes gastric cancer cell tumorigenesis
Sign Up to like & getrecommendations! Published in 2022 at "Technology and Health Care"
DOI: 10.3233/thc-thc228039
Abstract: BACKGROUND: Yes-associated protein (YAP) has been reported to act as a candidate human oncogene and played a critical role in the development of multiple cancer types. OBJECTIVE: We aimed to investigate the expression, function, and… read more here.
Keywords: cell; yes associated; yap; gastric cancer ... See more keywords