Elevated YKL-40 serum levels may contribute to wet age-related macular degeneration via the ERK1/2 pathway.
Sign Up to like & getrecommendations! Published in 2021 at "FEBS open bio"
DOI: 10.1002/2211-5463.13223
Abstract: Choroidal neovascularization (CNV) is a key characteristic of wet age-related macular degeneration (AMD) that can lead to severe vision loss in the elderly. Anti-VEGF therapy is currently the premier strategy for wet AMD, but it… read more here.
Keywords: age related; erk1 pathway; wet age; wet amd ... See more keywords
Combined plasma C‐reactive protein, interleukin 6 and YKL‐40 for detection of cancer and prognosis in patients with serious nonspecific symptoms and signs of cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5455
Abstract: Inflammation is a hallmark of cancer and its progression. Plasma levels of C‐reactive protein (CRP), interleukin‐6 (IL‐6) and YKL‐40 reflect inflammation, and are elevated in patients with cancer. This study investigated whether plasma CRP, IL‐6… read more here.
Keywords: interleukin ykl; combined plasma; reactive protein; cancer ... See more keywords
Clinical value of YKL‐40 in patients with polymyositis/dermatomyositis: A cross‐sectional study and a systematic review
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24605
Abstract: We performed a cross‐sectional study to investigate the clinical usefulness of YKL‐40 in patients with dermatomyositis (DM) and conducted a systematic review to summarize the clinical value of YKL‐40 in patients with polymyositis (PM)/DM. read more here.
Keywords: clinical value; sectional study; cross sectional; systematic review ... See more keywords
Assessment of YKL-40, lipid profile, antioxidant status, and some trace elements in benign and malignant breast proliferation.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05756-1
Abstract: Breast cancer is mainly the common form of cancer in women and is a leading cause of death worldwide associated with cancer. The objective of this study was to assess the possible association of lipid… read more here.
Keywords: lipid profile; breast; breast cancer; cancer ... See more keywords
Serum YKL-40 as a biomarker for liver fibrosis in chronic hepatitis B patients with normal and mildly elevated ALT
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DOI: 10.1007/s15010-018-1136-2
Abstract: PurposeYKL-40 is a chitinase-like protein expressed in multiple tissues including liver and is reported as a fibrosis marker. This study aimed to determine whether YKL-40 could serve as a diagnostic marker for the assessment of… read more here.
Keywords: fibrosis; liver fibrosis; hepatitis patients; chronic hepatitis ... See more keywords
Clinical utility of pleural fluid YKL-40 as a marker of malignant pleural effusion.
Sign Up to like & getrecommendations! Published in 2018 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2018.10.001
Abstract: Pleural effusion is a common presenting feature of malignancy. Malignant pleural effusion is primarily diagnosed by pleural fluid cytology, pleural biopsy, and tumor markers. The glycoprotein YKL-40 is a new tumor marker that has shown… read more here.
Keywords: effusion; malignant pleural; pleural effusion; pleural fluid ... See more keywords
YKL-40 can promote angiogenesis in sporadic cerebral cavernous malformation (CCM)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2019.03.035
Abstract: The factors affecting the formation of sporadic CCMs remain unclear. A cDNA microarray was used to identify characteristic gene expression patterns in sporadic CCMs. Transcription level of YKL-40 was confirmed by reverse transcription-polymerase chain reaction… read more here.
Keywords: sporadic ccms; formation; ccm; expression ... See more keywords
High YKL-40 is associated with poor survival in patients with renal cell carcinoma: a novel independent prognostic marker
Sign Up to like & getrecommendations! Published in 2017 at "Scandinavian Journal of Urology"
DOI: 10.1080/21681805.2017.1327885
Abstract: Abstract Objective: YKL-40 is an inflammation-associated glycoprotein supposed to have a role in cell survival and angiogenesis. Renal cell carcinoma (RCC) is characterized by varying prognosis and risk of relapse after a disease-free period of… read more here.
Keywords: associated poor; rcc; survival patients; cell ... See more keywords
OP0134 MACROPHAGES SKEWED BY GM-CSF PRODUCE YKL-40, INSTIGATING ANGIOGENESIS IN GIANT CELL ARTERITIS
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2020-eular.4455
Abstract: Background: Giant cell arteritis (GCA) is an inflammatory disease affecting the medium- and large-sized arteries. The pathology of GCA is characterized by an infiltrate of mainly CD4+ T-cells and macrophages. These macrophages release a wide… read more here.
Keywords: gca; cd206; none declared; ykl ... See more keywords
Serum YKL-40 as predictor of outcome in hypersensitivity pneumonitis
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DOI: 10.1183/13993003.01924-2015
Abstract: YKL-40, a chitinase-like protein mainly secreted by macrophages, neutrophils and epithelial cells, is increased in patients with idiopathic interstitial pneumonia and sarcoidosis. We aimed to investigate the role of YKL-40 as a biomarker in hypersensitivity… read more here.
Keywords: serum ykl; baseline; hypersensitivity pneumonitis; ykl ... See more keywords
YKL-40 is highly expressed in the epicardial adipose tissue of patients with atrial fibrillation and associated with atrial fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-018-1598-0
Abstract: BackgroundYKL-40 (CHI3L1) is a novel biomarker for inflammation, tissue remodeling, and fibrosis, as well as cardiovascular diseases. We investigated the association between YKL-40 expression in epicardial adipose tissue (EAT) and atrial fibrosis in patients with… read more here.
Keywords: epicardial adipose; tissue; atrial fibrosis; adipose tissue ... See more keywords