Synthesis, inhibition studies against AChE and BChE, drug-like profiling, kinetic analysis and molecular docking studies of N-(4-phenyl-3-aroyl-2(3H)-ylidene) substituted acetamides
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DOI: 10.1016/j.molstruc.2019.127459
Abstract: Abstract Halogenated and non-halogenated N-(4-phenyl-3-aroyl-2(3H)-ylidene) substituted acetamides were prepared by base-catalyzed cyclization of corresponding acetyl thioureas with phenacyl bromide. The synthesized compounds were structurally characterized by 1H NMR and 13C NMR spectroscopy and were screened… read more here.
Keywords: phenyl aroyl; ache bche; aroyl ylidene; inhibition ... See more keywords
Synthesis of Isoquinoline-Derived Diene Esters and Quinolin-2(1H)-ylidene-Substituted 1,5-Diones from Enynones and (Iso) Quinoline N-Oxides.
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DOI: 10.1021/acs.orglett.2c03915
Abstract: An efficient synthetic method was developed to access isoquinoline-derived diene esters from enynones and isoquinoline-N-oxides in an atom-economic manner. The isoquinoline-substituted diene esters were obtained in moderate to excellent yields via [3 + 2]-cycloaddition and… read more here.
Keywords: ylidene substituted; diene esters; isoquinoline; quinolin ylidene ... See more keywords