A Cell Type Selective YM155 Prodrug Targets Receptor-Interacting Protein Kinase 2 to Induce Brain Cancer Cell Death.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c11715
Abstract: Glioblastoma (GBM) is the most prevalent and aggressive primary central nervous system (CNS) malignancy. YM155 is a highly potent broad-spectrum anti-cancer drug that was derived from a phenotypic screen for functional inhibitors of survivin expression,… read more here.
Keywords: cell; brain; ym155; cancer ... See more keywords
Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03129-6
Abstract: Adverse side effects of cancer agents are of great concern in the context of childhood tumors where they can reduce the quality of life in young patients and cause life-long adverse effects. Synergistic drug combinations… read more here.
Keywords: neuroblastoma; drug; lapatinib; efflux transporter ... See more keywords
Broad-spectrum ubiquitin-specific protease inhibition as a mechanism for the cytotoxicity of YM155 in cancers
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DOI: 10.1038/s41598-025-88761-3
Abstract: Protein ubiquitination is a dynamic and reversible process involved in gene transcription, protein metabolism, and cellular apoptosis. Ubiquitin specific proteases (USPs), as the largest family of deubiquitinating enzymes, are able to remove the ubiquitin from… read more here.
Keywords: spectrum ubiquitin; broad spectrum; ym155; ubiquitin specific ... See more keywords
Abstract A016: Organotypic high-throughput screening identifies the combinatorial treatment of navitoclax and YM155 that target chemoresistant ovarian cancer cells
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DOI: 10.1158/1538-7445.ovarian23-a016
Abstract: The goal of this study was to identify a combination of drugs that targets the entire population of OvCa cells in combination with carboplatin. In preliminary experiments, we found that low proliferating subpopulations of ovarian… read more here.
Keywords: treatment; combination; ovarian cancer; cell ... See more keywords
YM155 Exerts Anti-Myeloma Effects Via Myc/BBC3 Signaling Pathway in Vitro
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DOI: 10.1182/blood-2024-205692
Abstract: Background: Our previous studies have demonstrated a strong link between Myc rearrangement (Myc-R) and poor prognosis in newly diagnosed multiple myeloma (NDMM). The survivin inhibitor YM155, a novel small molecule, is currently under clinical investigation… read more here.
Keywords: anti myeloma; myc; cell; ym155 ... See more keywords
Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis
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DOI: 10.2147/ott.s166798
Abstract: Purpose Strategies to increase radiosensitivity are urgently needed. Combining radiosensitizing reagents with radiotherapy could improve the outcome of cancer treatment. Some preclinical studies showed that sepantronium bromide (YM155) could sensitize cancer cells to radiation by… read more here.
Keywords: radiosensitivity; apoptosis; radiation induced; senescence ... See more keywords
Survivin inhibition with YM155 ameliorates experimental pulmonary arterial hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1145994
Abstract: Background: Imbalance between cell proliferation and apoptosis underlies the development of pulmonary arterial hypertension (PAH). Current vasodilator treatment of PAH does not target the uncontrolled proliferative process in pulmonary arteries. Proteins involved in the apoptosis… read more here.
Keywords: ym155; bcl2 mki67; expression survivin; pah ... See more keywords