Base-Promoted 5-exo-dig Cyclization of o-Alkynylamides or 2-En-4-ynamides with CO2 toward Fully Substituted Acrylates.
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DOI: 10.1021/acs.orglett.2c02123
Abstract: A base-promoted sequential cyclization and carboxylation of o-alkynylamides or 2-en-4-ynamides with CO2 has been achieved with high efficiency, stereoselectivity, and regioselectivity. This approach begins with 5-exo-dig cyclization followed by trapping the resulting vinyl anion with… read more here.
Keywords: base promoted; ynamides co2; alkynylamides ynamides; cyclization ... See more keywords