Copper-Catalyzed Dual Remote Asymmetric Vinylogous Alkynylallylic Substitution of Yne-Allylic Esters with Coumarins.
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DOI: 10.1021/acs.orglett.4c02199
Abstract: Chiral coumarins and their derivatives are ubiquitous structural motifs found in an array of biologically and therapeutically active natural products and drugs. Herein, a highly enantioselective dual remote copper-catalyzed vinylogous alkynylallylic substitution of yne-allylic esters… read more here.
Keywords: substitution yne; vinylogous alkynylallylic; dual remote; alkynylallylic substitution ... See more keywords
Copper-Catalyzed Enantioselective ε-Site Yne-Allylic Amination.
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DOI: 10.1021/acs.orglett.5c02805
Abstract: The development of highly selective and sustainable catalytic methods for the synthesis of enantiomerically chiral amines is of great interest and importance in both the pharmaceutical and fine chemical industries. Here, we have developed a… read more here.
Keywords: yne allylic; site yne; copper catalyzed; allylic amination ... See more keywords
Copper-catalysed asymmetric annulation of yne-allylic esters with amines to access axially chiral arylpyrroles
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DOI: 10.1038/s41467-024-50896-8
Abstract: The construction of atropisomers with 1,2-diaxes, while maintaining high enantiocontrol, presents a significant challenge due to the dynamic nature of steric hindrance at ortho-aryl substituents. Although various catalytic asymmetric methods have been developed for accessing… read more here.
Keywords: axially chiral; allylic esters; chiral arylpyrroles; copper catalysed ... See more keywords
Copper-catalyzed yne-allylic substitutions: concept and recent developments
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DOI: 10.3762/bjoc.20.232
Abstract: The catalytic (asymmetric) allylation and propargylation have been established as powerful strategies allowing access to enantioenriched α-chiral alkenes and alkynes. In this context, combining allylic and propargylic substitutions offers new opportunities to expand the scope… read more here.
Keywords: substitutions concept; allylic substitutions; catalyzed yne; copper catalyzed ... See more keywords