Base-mediated ynone-isocyanide [3+2] cycloaddition: a general method to 2,3,4-tri-substituted 1-H-pyrroles and bis-pyrroles.
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DOI: 10.1039/d3cc01586f
Abstract: A transition-metal-free and base-promoted one-pot synthesis of 2,3,4-trisubstituted 1-H-pyrroles has been developed. The reaction occurs through the [3+2] cycloaddition of differently functionalized ynones and isocyanides. The reaction's advantageous features are operational simplicity, atom economy, and… read more here.
Keywords: ynone isocyanide; isocyanide cycloaddition; mediated ynone; base mediated ... See more keywords