CRISPR/Cas9 mediated sequential editing of genes critical for ookinete motility in Plasmodium yoelii.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2016.12.010
Abstract: CRISPR/Cas9 has been successfully adapted for gene editing in malaria parasites including Plasmodium falciparum and Plasmodium yoelii. However, the reported methods were limited to editing one gene at a time. In practice, it is often… read more here.
Keywords: crispr; crispr cas9; yoelii; plasmodium ... See more keywords
cAMP-dependent protein kinase regulates secretion of apical membrane antigen 1 (AMA1) in Plasmodium yoelii.
Sign Up to like & getrecommendations! Published in 2021 at "Parasitology international"
DOI: 10.1016/j.parint.2021.102435
Abstract: Malaria remains a heavy global burden on human health, and it is important to understand the molecular and cellular biology of the parasite to find targets for drug and vaccine development. The mouse malaria model… read more here.
Keywords: camp dependent; dependent protein; yoelii; plasmodium yoelii ... See more keywords
The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.03.08.483432
Abstract: Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. As bioactive molecule, ceramide is involved in the regulation of many cellular processes. However, the impact of cell-intrinsic Ac… read more here.
Keywords: acid ceramidase; plasmodium; infection; yoelii ... See more keywords
Mast Cell Chymase/Mcpt4 Suppresses the Host Immune Response to Plasmodium yoelii, Limits Malaria-Associated Disruption of Intestinal Barrier Integrity and Reduces Parasite Transmission to Anopheles stephensi
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.801120
Abstract: An increase in mast cells (MCs) and MCs mediators has been observed in malaria-associated bacteremia, however, the role of these granulocytes in malarial immunity is poorly understood. Herein, we studied the role of mouse MC… read more here.
Keywords: mcpt4 mice; yoelii; immune response; mcpt4 ... See more keywords