Simultaneous quantification of the CYP2D6 substrate yohimbine, its metabolite 11-OH-yohimbine, and the CYP2D6 inhibitor paroxetine in human plasma
Sign Up to like & getrecommendations! Published in 2019 at "Analytical Methods"
DOI: 10.1039/c9ay01715a
Abstract: We developed and validated a human plasma LC-MS/MS assay according to FDA guidelines to determine the impact of the CYP2D6 inhibitor paroxetine on the pharmacokinetics of the assumed specific CYP2D6 substrate yohimbine. read more here.
Keywords: inhibitor paroxetine; cyp2d6 inhibitor; human plasma; cyp2d6 substrate ... See more keywords
A literature perspective on the pharmacological applications of yohimbine
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Medicine"
DOI: 10.1080/07853890.2022.2131330
Abstract: Abstract Introduction: Phytochemicals have garnered much attention because they are useful in managing several human diseases. Yohimbine is one such phytochemical with significant pharmacological potential and could be exploited for research by medicinal chemists. It… read more here.
Keywords: yohimbine; pharmacological applications; literature perspective; perspective pharmacological ... See more keywords
Modulation of formalin‐induced pain‐related behaviour by clonidine and yohimbine in the Speke's hinged tortoise (Kiniskys spekii)
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Veterinary Pharmacology and Therapeutics"
DOI: 10.1111/jvp.12374
Abstract: The study was designed to investigate the involvement of noradrenergic and serotonergic receptor systems in the modulation of formalin-induced pain-related behaviour in the Speke's hinged tortoise. Intradermal injection of 100 μL of formalin at a dilution… read more here.
Keywords: related behaviour; formalin; pain related; yohimbine ... See more keywords
Yohimbine-Induced Reactivity of Heart Rate Variability in Unmedicated Depressed Patients With and Without Adverse Childhood Experience
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2021.734904
Abstract: Stressful life events play a role in the pathogenesis of major depressive disorder (MDD) and many patients with MDD were exposed to developmental stress due to adverse childhood experiences (ACE). Furthermore, dysregulation of the autonomic… read more here.
Keywords: yohimbine; rate variability; hrv; ace ... See more keywords
Quantification of microdosed oral yohimbine and its major metabolite in human plasma in the picogram range.
Sign Up to like & getrecommendations! Published in 2019 at "Bioanalysis"
DOI: 10.4155/bio-2019-0129
Abstract: Aim: Pharmacokinetics after oral microdosing of the anticipated CYP2D6 substrate yohimbine and its metabolite 11-OH-yohimbine is potentially useful for drug-drug interaction trials and profiling of CYP2D6 enzyme activity. Materials & methods: We developed an ultrasensitive… read more here.
Keywords: plasma; range; microdosed oral; quantification microdosed ... See more keywords