Increasing O-GlcNAcylation is neuroprotective in young and aged brains after ischemic stroke
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2021.113646
Abstract: Spliced X-box binding protein-1 (XBP1s) together with the hexosamine biosynthetic pathway (HBP) and O-GlcNAcylation forms the XBP1s/HBP/O-GlcNAc axis. Our previous studies have provided evidence that activation of this axis is neuroprotective after ischemic stroke and… read more here.
Keywords: ischemic stroke; glcnacylation; increasing glcnacylation; young aged ... See more keywords
Calbindin-D28K, parvalbumin, and calretinin in young and aged human locus coeruleus
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.06.006
Abstract: Certain neuronal populations, including basal forebrain cholinergic neurons (BFCN) and noradrenergic neurons of the locus coeruleus (LC), are selectively vulnerable to pathology and loss early in the course of aging and Alzheimer's disease (AD). Human… read more here.
Keywords: aged human; calbindin d28k; parvalbumin calretinin; locus coeruleus ... See more keywords
Effects of exercise training on neuromuscular junctions and their active zones in young and aged muscles
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.07.001
Abstract: The neuromuscular junction (NMJ) connects the motor neuron with myofibers allowing muscle contraction. Both aging and increased activity result in NMJ remodeling. Here, the effects of exercise were examined in young and aged soleus muscles.… read more here.
Keywords: active zones; aged muscles; training neuromuscular; young aged ... See more keywords
Poststroke Exercise is as Effective as Skilled Rehabilitation: Effects in Young and Aged Mice
Sign Up to like & getrecommendations! Published in 2018 at "Behavioral Neuroscience"
DOI: 10.1037/bne0000268
Abstract: Stroke is a leading cause of long-term disability, though current rehabilitative strategies fail to yield complete recovery. Focused training of the impaired limb improves functional outcome in rodents, but these strategies require intensive training that… read more here.
Keywords: poststroke exercise; young aged; aged mice; rehabilitation ... See more keywords
Differential effects in young and aged rats' navigational accuracy following instantaneous rotation of environmental cues.
Sign Up to like & getrecommendations! Published in 2022 at "Behavioral neuroscience"
DOI: 10.1037/bne0000536
Abstract: Successful navigation depends critically upon two broad categories of spatial navigation strategies that include allocentric and egocentric reference frames, relying on external or internal spatial information, respectively. As with older adults, aged rats show robust… read more here.
Keywords: young aged; aged rats; rotation; aged animals ... See more keywords
Circadian monitoring as an aging predictor
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-33195-3
Abstract: The ageing process is associated with sleep and circadian rhythm (SCR) frailty, as well as greater sensitivity to chronodisruption. This is essentially due to reduced day/night contrast, decreased sensitivity to light, napping and a more… read more here.
Keywords: decision; temperature; monitoring aging; young aged ... See more keywords
Impacts of Aging and Blackcurrant Supplementation on the Gut Microbiome Profile of Female Mice (P20-031-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz040.p20-031-19
Abstract: Objectives Blackcurrant, an anthocyanin-rich berry, has multiple health benefits. The purpose of this study was to examine the impacts of blackcurrant supplementation and aging on gut bacterial communities in female mice. Methods Three-month and 18-month… read more here.
Keywords: gut microbiome; abundance; mice; female mice ... See more keywords
Regulation of fractone heparan sulfate composition in young and aged subventricular zone neurogenic niches.
Sign Up to like & getrecommendations! Published in 2021 at "Glycobiology"
DOI: 10.1093/glycob/cwab081
Abstract: Fractones, specialized extracellular matrix structures found in the subventricular zone (SVZ) neurogenic niche, can capture growth factors, such as basic fibroblast growth factor, from the extracellular milieu through a heparin-binding mechanism for neural stem cell… read more here.
Keywords: subventricular zone; dko mice; heparan sulfate; young aged ... See more keywords
THE IMPORTANCE OF THE SYMPTOMS FOR DIAGNOSING AND TREATING OF HYPERTENSION IN CHILDREN, ADOLESCENTS AND YOUNG-AGED, ASSESSED WITH APPLANATION TONOMETRY
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000836904.20225.c7
Abstract: Objective: The aim is to know if the presence of symptoms in children, adolescents, and young-aged are important for early diagnosis and therapy of hypertension. Design and method: For this cross-sectional study was entered 180… read more here.
Keywords: adolescents young; hypertension; young aged; group ... See more keywords
Adiponectin receptors activation performs dual effects on regulating myogenesis and adipogenesis of young and aged muscle satellite cells
Sign Up to like & getrecommendations! Published in 2022 at "Cell Proliferation"
DOI: 10.1111/cpr.13370
Abstract: Skeletal muscle mass and function deteriorate with ageing. Adiponectin receptors (APNrs), mainly activated by adiponectin, participate in various physiological activities and have varying signalling pathways at different ages. This study aimed to explore whether discrepant… read more here.
Keywords: satellite cells; adiponectin receptors; muscle satellite; young aged ... See more keywords
Very Low Efficiency of Direct Reprogramming of Astrocytes Into Neurons in the Brains of Young and Aged Mice After Cerebral Ischemia
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2019.00334
Abstract: After cerebral ischemia, the ratio between astroglial cells and neurons in the neurovascular unit is disrupted in the perilesional area. We hypothesized that restoring the balance within the neurovascular unit may lead to an improved… read more here.
Keywords: cerebral ischemia; young aged; aged mice; ischemia ... See more keywords